Die Rolle der endothelialen Progenitorzellen und Gefäßsteifigkeit bei Patienten mit Psoriasis-Arthritis

Sugiarto, Natalina Rosekie

dc.contributor.advisor	Patschan, Susann PD Dr.
dc.contributor.author	Sugiarto, Natalina Rosekie
dc.date.accessioned	2020-09-03T12:18:17Z
dc.date.available	2020-10-14T22:50:03Z
dc.date.issued	2020-09-03
dc.identifier.uri	http://hdl.handle.net/21.11130/00-1735-0000-0005-1474-2
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8183
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8183
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Die Rolle der endothelialen Progenitorzellen und Gefäßsteifigkeit bei Patienten mit Psoriasis-Arthritis	de
dc.type	doctoralThesis	de
dc.title.translated	Early endothelial progenitor cells and vascular stiffness in psoriasis and psoriatic arthritis	de
dc.contributor.referee	Patschan, Susann PD Dr.
dc.date.examination	2020-10-07
dc.description.abstracteng	Background: Both psoriasis (Ps) and psoriasis arthritis (PsA) have been associated with increased cardiovascular risk. Also, both are characterized by increased neovascularization. Endothelial progenitor cells (EPCs) have been implicated in promoting vascular repair in ischemic diseases. The aim of the study was to correlate the EPC system with CV risk factors and with parameters of vascular stiffness in Ps and PsA. Methods: Twenty-six healthy subjects, 30 patients with Ps, and 31 patients PsA were included in the study. eEPC regeneration was evaluated by a colony-forming assay, circulating eEPCs were measured by cytometric analysis. For vascular analysis, all subjects underwent quantification of pulse wave velocity (PWV) and augmentation index (AIX). Results: Patients were categorized upon the duration of disease, severity of skin involvement (PASI-Ps), individual pain as reflected by the VAS (PsA), CRP values, and history of treatment with one or more biologicals. Regarding the eEPC system, no significant differences were observed between the respective categories. Correlation analyses between parameters of vascular stiffness (PWV and AIX) and patterns of colony formation/circulating eEPCs did not show any correlation at all. Conclusion: Parameters of vascular stiffness are not significantly deteriorated in Ps/PsA. Thus, pulse wave analysis may not be suitable for CVR assessment in certain autoimmune-mediated diseases. Regenerative activity of the eEPC system/circulating eEPC numbers are not altered in Ps/PsA. One may conclude that malfunctions of the eEPC are not substantially involved in perpetuating the micro-/macrovascular alterations in Ps/PsA.	de
dc.contributor.coReferee	Mößner, Rotraut Prof. Dr.
dc.subject.eng	eEPCs	de
dc.subject.eng	Ps	de
dc.subject.eng	PsA	de
dc.subject.eng	CVR	de
dc.subject.eng	Pulse wave velocity	de
dc.identifier.urn	urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-1474-2-5
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	GOK-MEDIZIN	de
dc.description.embargoed	2020-10-14
dc.identifier.ppn	1728853850

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Human- und Zahnmedizin [2870]

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