Site-Selectivity in Ruthenium-Catalyzed C–H and C–C Activations
von Korkit Korvorapun
Datum der mündl. Prüfung:2020-09-16
Erschienen:2020-09-23
Betreuer:Prof. Dr. Lutz Ackermann
Gutachter:Prof. Dr. Lutz Ackermann
Gutachter:Prof. Dr. Konrad Koszinowski
Gutachter:Prof. Dr. Dr. Lutz Tietze
Gutachter:Prof. Dr. Dietmar Stalke
Gutachter:Prof. Dr. Johannes Jun.-Walker
Gutachter:Dr. Michael John
Dateien
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Description:Dissertation_Korkit
Zusammenfassung
Englisch
During the past decades, transition metal-catalyzed C–H and C–C activation has been recognized as a powerful platform in organic synthesis to access the selective construction of new C–C and C–Het bonds. The full control of the site-selectivity is one of the key challenges for C–H and C–C transformations. In this context, chelation assistance of a directing group has become an efficient method for ortho-selective C–H and C–C activation of arenes. In contrast to other transition metals, cyclometalated ruthenium complexes exhibit distinct properties, thus allowing for the formation of new C–C and C–Het bonds on the arene at the position ortho, meta, or para to the directing group. Within this thesis, ruthenium catalysis was utilized for meta-selective C–H functionalizations, including alkylations, benzylations and brominations. In addition to the remote transformations, the concept of ruthenium-catalyzed C–H activation could be employed for the direct arylations under photoredox catalysis.
Keywords: Transition Metal Catalysis; Ruthenium; C–C Activation; C–H Activation; meta-Selectivity; ortho-Selectivity; Remote Functionalization; Photoredox Catalysis