Allergische und irritative Kontaktdermatitis in Filaggrin- und Hornerin-defizienten Mäusen

Dettmann, Judith Maria

dc.contributor.advisor	Schön, Michael P. Prof. Dr.
dc.contributor.author	Dettmann, Judith Maria
dc.date.accessioned	2020-10-13T12:31:12Z
dc.date.available	2020-10-27T23:50:03Z
dc.date.issued	2020-10-13
dc.identifier.uri	http://hdl.handle.net/21.11130/00-1735-0000-0005-14AF-0
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8225
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8225
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Allergische und irritative Kontaktdermatitis in Filaggrin- und Hornerin-defizienten Mäusen	de
dc.type	doctoralThesis	de
dc.title.translated	Allergic and irritant contact dermatitis in filaggrin-hornerin (FlgHrnr−/−) double-deficient mice	de
dc.contributor.referee	Walter, Lutz Prof. Dr.
dc.date.examination	2020-10-20
dc.description.abstracteng	The two epithelial structural proteins filaggrin (Flg) and hornerin (Hrnr) play a major role in upholding the integrity of the skin barrier function. Loss-of-function mutations in these genes cause an epidermal barrier deficiency. The missing expression of Flg and Hrnr is independently associated with impaired barrier diseases, such as atopic dermatitis. Little data are available on the association with contact dermatitis. However, with an estimated prevalence of 15-20% in the population, contact dermatitis is a socially and economically highly relevant disease. Contact dermatitis is divided into allergic (ACD) and irritant (ICD) contact dermatitis. ACD is a T cell-mediated delayed-type hypersensitivity reaction. The response depends on the activation of the adaptive immune system. ICD is a non-specific inflammatory dermatitis that involves the innate immune system only. This work investigates the relation between epidermal barrier deficiency in filaggrin-hornerin (FlgHrnr−/−) double-deficient mice and contact dermatitis. Ear thickness change was measured over a period of time as a parameter for the induced skin inflammation. FlgHrnr−/− mice showed a lower hapten threshold and therefore an elevated susceptibility to ACD. The distribution, quantity and quality of the inflammatory cell infiltration has been examined by using flow cytometry, histology and immunohistochemistry. Results suggest that a disrupted immune regulation in ACD leads to an excessive inflammation. In ICD there was no difference in ear thickness or composition of cell infiltration detected. The novel FlgHrnr−/− mouse model allows better understanding of the pathogenic mechanisms (“outside-in” hypothesis) in ACD.	de
dc.contributor.coReferee	Oppermann, Martin Prof. Dr.
dc.subject.ger	Kontaktdermatitis	de
dc.subject.ger	Filaggrin	de
dc.subject.ger	Hornerin	de
dc.subject.ger	Hautbarriere	de
dc.subject.eng	contact dermatitis	de
dc.subject.eng	filaggrin	de
dc.subject.eng	hornerin	de
dc.subject.eng	skin barrier	de
dc.identifier.urn	urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-14AF-0-8
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.description.embargoed	2020-10-27
dc.identifier.ppn	1735493244

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Human- und Zahnmedizin [2872]

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