dc.contributor.advisor | Missbach-Güntner, Jeannine Dr. | |
dc.contributor.author | Eckardt, Jan-Niklas | |
dc.date.accessioned | 2020-10-23T14:06:01Z | |
dc.date.available | 2020-11-10T23:50:02Z | |
dc.date.issued | 2020-10-23 | |
dc.identifier.uri | http://hdl.handle.net/21.11130/00-1735-0000-0005-14BF-E | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-8263 | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-8263 | |
dc.language.iso | deu | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.ddc | 610 | de |
dc.title | Evaluation der Interaktionen zwischen extrazellulärer Matrix und ausgewählten tumorassoziierten Proteinen mittels Nahinfrarot-Antikörpern | de |
dc.type | doctoralThesis | de |
dc.title.translated | Evaluation of interactions between the extracellular matrix and selected tumor-associated proteins with near-infrared antibodies | de |
dc.contributor.referee | Alves, Frauke Prof. Dr. | |
dc.date.examination | 2020-10-29 | |
dc.description.abstracteng | The interplay between tumor cells and their microenvironment is crucial for carcinogenesis and tumor progression. In my thesis, I examine selected tumor-associated proteins that interact with the extracellular matrix surrounding tumor cells by evaluating their interactions with selected antibodies that are conjugated to near-infrared fluorophors (NIRF) in vitro and in vivo. I demonstrate an identical pattern of biodistribution of NIRF-antibodies independent of tumor model, tumor transplantation mode in vivo, conjugated fluorophore and temporal dynamics. Further, in a two-dimensional in vitro model I demonstrate the upregulation of a selected tumor-associated protein in response to chemotherapy with concomitant cell lysis whereas in a three-dimensional model chemotherapy selected a more aggressive phenotype of tumor cells clearly underlining distinct differences between different dimensional models in cell culture. | de |
dc.contributor.coReferee | Wouters-Bunt, Freddy Prof. Dr. | |
dc.subject.eng | Extracellular Matrix | de |
dc.subject.eng | EpCAM | de |
dc.subject.eng | Lysyloxidase | de |
dc.subject.eng | CD44 | de |
dc.subject.eng | Tumor Spheroid | de |
dc.subject.eng | Near-Infrared Antibody | de |
dc.identifier.urn | urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-14BF-E-9 | |
dc.affiliation.institute | Medizinische Fakultät | de |
dc.subject.gokfull | Innere Medizin - Allgemein- und Gesamtdarstellungen (PPN619875747) | de |
dc.description.embargoed | 2020-11-10 | |
dc.identifier.ppn | 1736532138 | |