The αE(CD103)β7 integrin and its role on regulatory T-cells in allergic contact dermatitis

by Jan-Hendrik Bernhard Hardenberg
Doctoral thesis
Date of Examination:2020-11-05
Date of issue:2020-10-26
Advisor:Prof. Dr. Michael P Schoen
Referee:Prof. Dr. Jürgen Wienands
Referee:Prof. Dr. Thomas Meyer
Persistent Address: http://dx.doi.org/10.53846/goediss-8256

 

 

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Abstract

English

The aim of this study was to determine whether CD103 deficiency causes an impairment in the regulatory function of Tregs in allergic contact dermatitis and to investigate possible mechanisms. This study found that Tregs from CD103-/- are dysfunctional in both the sensitization and the effector phase explaining the aggravated CHS response of CD103-/-mice. Furthermore, evidence for an impairment of the ability of Tregs in CD103-/- mice to be activated was found. These findings imply that Tregs in CD103-/- mice are fundamentally dysfunctional. Further experiments are needed to elucidate how CD103 controls Treg function. This study shows that CD103 is not only a marker for a Treg subset, but also of significance for Treg function in the context of allergic contact dermatitis
Keywords: Allergic contact dermatitis; Regulatory T cells
 
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