Constitutive Modeling for Tissue Engineered Heart Repair

Kalhöfer-Köchling, Moritz

dc.contributor.advisor	Wang, Yong Dr.
dc.contributor.author	Kalhöfer-Köchling, Moritz
dc.date.accessioned	2020-10-27T15:27:27Z
dc.date.available	2020-10-27T15:27:27Z
dc.date.issued	2020-10-27
dc.identifier.uri	http://hdl.handle.net/21.11130/00-1735-0000-0005-14C6-5
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8279
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8279
dc.language.iso	eng	de
dc.relation.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	571.4	de
dc.title	Constitutive Modeling for Tissue Engineered Heart Repair	de
dc.type	doctoralThesis	de
dc.contributor.referee	Hohage, Thorsten Prof. Dr.
dc.date.examination	2020-09-25
dc.description.abstracteng	Computer-aided therapy design is an intricate endeavor intertwining all scales from molecules to cells and tissues to organs. Changing one such component in a living system can have far-reaching effects, diffcult to estimate, which some times only unfold after months or even years. Thus, a detailed understanding of the key players is crucial for appropriate diagnosis and treatment planning. Concerning heart failure patients, scarred tissue shows adverse effects for the electrophysiology, electromechanics, and hemodynamics. In this work, I present the orthotropic nature of myocardium, what implications it has for the cardiac cycle, and how the arising structural mechanics can be captured in quasi-stationary simulations using constitutive modeling. The results are combined with modern technology of artificial heart muscle engineering to research optimal patch design for cardiac wound healing.	de
dc.contributor.coReferee	Enderlein, Jörg Prof. Dr.
dc.contributor.thirdReferee	Zimmermann, Wolfram-Hubertus Prof. Dr.
dc.contributor.thirdReferee	Boretius, Susann Prof. Dr.
dc.contributor.thirdReferee	Rehfeldt, Florian Dr.
dc.subject.eng	Cardiac	de
dc.subject.eng	Heart	de
dc.subject.eng	Structural Mechanics	de
dc.subject.eng	Engineered	de
dc.subject.eng	EHM	de
dc.subject.eng	Tissue	de
dc.subject.eng	Fiber	de
dc.subject.eng	Constitutive Modeling	de
dc.identifier.urn	urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-14C6-5-6
dc.affiliation.institute	Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB)	de
dc.subject.gokfull	Biologie (PPN619462639)	de
dc.identifier.ppn	173683746X

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GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften [1031]
GGNB - Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences

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