Bildqualität und Funktionsanalyse von Real-Time-Herz-MRT-Untersuchungen bei 3,0 T: Volumetrie mit Vergleich zweier Softwareprototypen und Analyse der myokardialen Deformation im Sinusrhythmus und bei Vorhofflimmern

Laubrock, Kerstin

dc.contributor.advisor	Unterberg-Buchwald, Christina Prof. Dr.
dc.contributor.author	Laubrock, Kerstin
dc.date.accessioned	2020-11-09T15:00:44Z
dc.date.available	2020-11-26T23:50:03Z
dc.date.issued	2020-11-09
dc.identifier.uri	http://hdl.handle.net/21.11130/00-1735-0000-0005-14E0-7
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8283
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8283
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Bildqualität und Funktionsanalyse von Real-Time-Herz-MRT-Untersuchungen bei 3,0 T: Volumetrie mit Vergleich zweier Softwareprototypen und Analyse der myokardialen Deformation im Sinusrhythmus und bei Vorhofflimmern	de
dc.type	doctoralThesis	de
dc.title.translated	Image quality and functional analysis in Real-Time-CMR in 3.0 T: volumetry comparing two software prototypes and myoakardial deformation in sinus rhythm and atrial fibrillation	de
dc.contributor.referee	Unterberg-Buchwald, Christina Prof. Dr.
dc.date.examination	2020-11-19
dc.description.abstractger	Die Bewertung der kardialen Funktion einschließlich der myokardialen Deformation, zu Englisch Strain, ist fundamental für Behandlungsentscheidungen bei herzkranken Patienten und kann mit Hilfe der Magnet Resonanz Tomografie (MRT) zuverlässig durchgeführt werden. Allerdings führen Arrhythmien (z.B. Vorhofflimmern) bei herkömmlichen CINE bSSFP Sequenzen oftmals zu einer eingeschränkten Bildqualität und resultierend schlechteren Beurteilbarkeit der Herzfunktion. Die Real Time bSSFP Sequenz hingegen zeigt sich robust gegen Arrhythmie bedingte Artefakte und bietet zugleich mehrere Herzschläge für die Funktionsanalyse. Das Ziel dieser Studie war, die Durchführbarkeit und Vergleichbarkeit der kardialen MRT Strain Analyse an RT Aufnahmen von Probanden im Sinusrhythmus (SR) und Patienten im Vorhofflimmern (VHF) zu belegen.	de
dc.description.abstracteng	Background: Myocardial stain offers an additive diagnostic and predictive factor in different cardiovascular diseases. While echocardiography is still the supreme cheap and most accessible method, CMR represents the more exact modality. However, in arrhythmia conventional CINE CMR is hampered by reconstruction artifacts caused by inconsistent data from multiple heartbeats. A rapid signal processing as Real-Time (RT) MRI at high temporal resolution might allow reliable analysis of deformation and volumetry during arrhythmia. Methods: A total of 30 patients with atrial fibrillation and 20 subjects in sinus rhythm were prospectively included and underwent 3.0 T RT and standard CINE CMR protocol. RT CMR acquisition was performed without cardiac gating and during free breathing, record multiple consecutive beats. Three consecutive RT beats and the corresponding CINE beat were used to determine single-layer longitudinal, circumferential and radial strain using CMR-FT software QStrain (Medis, Netherlands). Correlation of CINE and RT analysis was calculated using Pearson and Spearman method, moreover intra- and interobserver variability was tested. Additionally image quality and left ventricular volumetry was determined. Results: Single beat strain analysis was successfully performed in RT CMR of subjects with atrial fibrillation. Compared to the corresponding RT strain analysis, a higher proportion of CINE images showed insufficient tracking. Strain analysis of RT and CINE CMR showed a significant high correlation in both groups. In patients with atrial fibrillation RT CMR resulted in a mostly significantly higher image quality compared to CINE imaging, whereas during sinus rhythm conventional CINE images were superior concerning diagnostic quality. RT CMR resulted in slightly lower strain and functional values than CINE CMR. Conclusion: CINE CMR strain analysis in arrhythmic beats is error-prone. RT CMR improves image quality in arrhythmic patients, allowing a reliable FT strain analysis. Strain analysis as well as volumetric analysis is feasible with slightly lower values relative to CINE CMR. Until now, only single beat analysis is possible, to use the full potential of consecutive RT beats there is a need for a further development of post processing software.	de
dc.contributor.coReferee	Schuster, Andreas Prof. Dr. Dr.
dc.contributor.thirdReferee	Meyer, Thomas Prof. Dr.
dc.subject.ger	Real Time	de
dc.subject.ger	CMR	de
dc.subject.ger	Feature Tracking	de
dc.subject.ger	CINE	de
dc.subject.eng	Real Time	de
dc.subject.eng	CINE	de
dc.subject.eng	Feature Tracking	de
dc.subject.eng	CMR	de
dc.identifier.urn	urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-14E0-7-1
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.subject.gokfull	Methoden und Techniken in der Medizin (PPN619875143)	de
dc.subject.gokfull	Diagnostik {Medizin} (PPN619875739)	de
dc.description.embargoed	2020-11-26
dc.identifier.ppn	1738280926

Dateien

Name:Doktorarbeit Laubrock Stand 30.10.2020 ohne Lebenslauf.pdf

Größe:1.745Mb

Format:PDF

Öffnen

Name:: Doktorarbeit Laubrock Stand ...
Größe:: 1.745Mb
Format:: PDF

Öffnen

Das Dokument erscheint in:

Human- und Zahnmedizin [2872]

Zur Kurzanzeige