Die anaplastische Lymphomkinase (ALK) im Fokus der genomischen Instabilität des Neuroblastoms: Funktionale und morphometrische Untersuchungen

The Anaplastic lymphoma kinase (ALK) in the focus of genomic instability of neuroblastoma: functional and morphometric studies

by Basel Kharbot
Doctoral thesis
Date of Examination:2020-11-02
Date of issue:2020-11-13
Advisor:Prof. Dr. Freddy Wouters-Bunt
Referee:Prof. Dr. Freddy Wouters-Bunt
Referee:Prof. Dr. Stefan Jakobs
Referee:Prof. Dr. Rainer Mausberg
Persistent Address: http://dx.doi.org/10.53846/goediss-8290

 

 

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Abstract

English

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase belonging to the family of insulin receptors. It is considered to be a potential driver for the development of neuroblastoma, a complex and often therapy-resistant cancer, since genetic changes such as amplifications or point mutations of ALK can be detected in hereditary and sporadic neuroblastoma cases and lead to deregulated kinase activity. Still, the etiology of Neuroblastoma disease is not completely understood. This thesis investigates the influence of ALK as wild type and point mutations F1174L, R1275Q and I1250T on functional and morphological characteristics of neuroblastoma cells as these could serve as a potential indicator for malignant behavior.
Keywords: neuroblastoma; ALK; cell morphology
Schlagwörter: Neuroblastom; ALK; Zellmorphologie