Die anaplastische Lymphomkinase (ALK) im Fokus der genomischen Instabilität des Neuroblastoms: Funktionale und morphometrische Untersuchungen

Kharbot, Basel

dc.contributor.advisor	Wouters-Bunt, Freddy Prof. Dr.
dc.contributor.author	Kharbot, Basel
dc.date.accessioned	2020-11-13T11:30:36Z
dc.date.available	2022-12-16T00:50:11Z
dc.date.issued	2020-11-13
dc.identifier.uri	http://hdl.handle.net/21.11130/00-1735-0000-0005-14EA-D
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8290
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8290
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Die anaplastische Lymphomkinase (ALK) im Fokus der genomischen Instabilität des Neuroblastoms: Funktionale und morphometrische Untersuchungen	de
dc.type	doctoralThesis	de
dc.title.translated	The Anaplastic lymphoma kinase (ALK) in the focus of genomic instability of neuroblastoma: functional and morphometric studies	de
dc.contributor.referee	Wouters-Bunt, Freddy Prof. Dr.
dc.date.examination	2020-11-02
dc.description.abstracteng	Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase belonging to the family of insulin receptors. It is considered to be a potential driver for the development of neuroblastoma, a complex and often therapy-resistant cancer, since genetic changes such as amplifications or point mutations of ALK can be detected in hereditary and sporadic neuroblastoma cases and lead to deregulated kinase activity. Still, the etiology of Neuroblastoma disease is not completely understood. This thesis investigates the influence of ALK as wild type and point mutations F1174L, R1275Q and I1250T on functional and morphological characteristics of neuroblastoma cells as these could serve as a potential indicator for malignant behavior.	de
dc.contributor.coReferee	Jakobs, Stefan Prof. Dr.
dc.contributor.thirdReferee	Mausberg, Rainer Prof. Dr.
dc.subject.ger	Neuroblastom	de
dc.subject.ger	ALK	de
dc.subject.ger	Zellmorphologie	de
dc.subject.eng	neuroblastoma	de
dc.subject.eng	ALK	de
dc.subject.eng	cell morphology	de
dc.identifier.urn	urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-14EA-D-4
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	GOK-MEDIZIN	de
dc.description.embargoed	2022-12-16
dc.identifier.ppn	1738714071

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Human- und Zahnmedizin [2872]

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