| dc.contributor.advisor | Psychogios, Marios-Nikos Prof. Dr. | |
| dc.contributor.author | Tsogkas, Ioannis | |
| dc.date.accessioned | 2020-11-27T09:55:48Z | |
| dc.date.available | 2020-12-10T23:50:02Z | |
| dc.date.issued | 2020-11-27 | |
| dc.identifier.uri | http://hdl.handle.net/21.11130/00-1735-0000-0005-1503-0 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-8333 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-8333 | |
| dc.language.iso | deu | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.ddc | 610 | de |
| dc.title | Wert des CBV-ASPECTS im Vergleich zum CTA-ASPECTS bei Patienten mit akutem ischämischem Schlaganfall | de |
| dc.type | doctoralThesis | de |
| dc.title.translated | Added value of CT perfusion compared to CT angiography in predicting clinical outcomes of stroke patients treated with mechanical thrombectomy | de |
| dc.contributor.referee | Psychogios, Marios-Nikos Prof. Dr. | |
| dc.date.examination | 2020-12-03 | |
| dc.description.abstracteng | Objectives CTP images analyzed with the Alberta stroke program
early CT scale (ASPECTS) have been shown to be optimal
predictors of clinical outcome. In this study we compared
two biomarkers, the cerebral blood volume (CBV)-
ASPECTS and the CTA-ASPECTS as predictors of clinical
outcome after thrombectomy.
Methods Stroke patients with thrombosis of the M1 segment
of the middle cerebral artery were included in our study. All
patients underwent initial multimodal CT with CTP and CTA
on a modern CT scanner. Treatment consisted of full dose
intravenous tissue plasminogen activator, when applicable,
and mechanical thrombectomy. Three neuroradiologists separately
scored CTP and CTA images with the ASPECTS score.
Results Sixty-five patients were included. Median baseline
CBV-ASPECTS and CTA-ASPECTS for patients with
favourable clinical outcome at follow-up were 8 [interquartile
range (IQR) 8-9 and 7-9 respectively]. Patients with poor clinical
outcome showed a median baseline CBV-ASPECTS of 6
(IQR 5-8, P< 0.0001) and a median baseline CTA-ASPECTS
of 7 (IQR 7-8, P = 0.18). Using CBV-ASPECTS and CTAASPECTS
raters predicted futile reperfusions in 96 % and
56 % of the cases, respectively.
Conclusions CBV-ASPECTS is a significant predictor of
clinical outcome in patients with acute ischemic stroke treated
with mechanical thrombectomy. | de |
| dc.contributor.coReferee | Döppner, Thorsten Roland Prof. Dr. | |
| dc.subject.eng | Neuroimaging | de |
| dc.subject.eng | Stroke | de |
| dc.subject.eng | Thrombectomy | de |
| dc.subject.eng | Patient selection | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-1503-0-5 | |
| dc.affiliation.institute | Medizinische Fakultät | de |
| dc.subject.gokfull | Medizin (PPN619874732) | de |
| dc.subject.gokfull | Radiologie / Bildgebende Verfahren / Ultraschall / Nuklearmedizin / Strahlenschutz - Allgemein- und Gesamtdarstellungen (PPN619875585) | de |
| dc.description.embargoed | 2020-12-10 | |
| dc.identifier.ppn | 1741436370 | |