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Vimentin protects differentiating stem cells from stress

dc.contributor.advisorKaganovich, Daniel Prof. Dr.
dc.contributor.authorPattabiraman, Sundararaghavan
dc.titleVimentin protects differentiating stem cells from stressde
dc.contributor.refereeGöpfert, Martin Prof. Dr.
dc.description.abstractengVimentin is the first cytoplasmic intermediate filament to be expressed in mammalian cells during early differentiation, but its role in cellular fitness has long been a mystery. Vimentin is acknowledged to play a role in cell stiffness, cell motility, and cytoplasmic organization, yet it is thought to be dispensable for cellular function and organismal development. Here, we show that Vimentin plays a role in cellular stress response in differentiating cells, by directly binding aggregates and RNA-binding proteins, directing their elimination and asymmetric partitioning. In the absence of Vimentin, pluripotent embryonic stem cells fail to differentiate properly, with a pronounced deficiency in neuronal differentiation. Our results uncover a novel function for Vimentin, with important implications for development, tissue homeostasis, and in particular, stress
dc.contributor.coRefereeOuteiro, Tiago Fleming Prof. Dr.
dc.subject.engVimentin, Intermediate Filaments, Aggregation, Stress Granules, RNP Granules, Asymmetric Inheritance, Aging, Differentiation, Embryonic Stem Cellsde
dc.affiliation.instituteBiologische Fakultät für Biologie und Psychologiede
dc.subject.gokfullBiologie (PPN619462639)de

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