Using n-layer graph models for representing and transforming knowledge on biological pathways

Hammoud, Zaynab

dc.contributor.advisor	Kramer, Frank Prof. Dr.
dc.contributor.author	Hammoud, Zaynab
dc.date.accessioned	2021-03-16T15:19:21Z
dc.date.available	2021-03-23T00:50:04Z
dc.date.issued	2021-03-16
dc.identifier.uri	http://hdl.handle.net/21.11130/00-1735-0000-0005-15A6-8
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8478
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8478
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	510	de
dc.title	Using n-layer graph models for representing and transforming knowledge on biological pathways	de
dc.type	doctoralThesis	de
dc.contributor.referee	Wingender, Edgar Prof. Dr.
dc.date.examination	2021-03-04
dc.description.abstracteng	Currently, the use of prior knowledge on biological pathways in research projects is often a manual process, not well documented and hard to reproduce. The aim of this thesis is the definition and implementation of a multi-layer pathway modeling framework. This includes the theoretical definition of the model, operations and an operational language for transforming model and standard operations, e.g. adding and removing nodes, edges and layers. An n-layer graph with nodes arranged within layers and connected via inter- and intra-layer edges will be used. Operations applicable to pathways will include the addition/removal/modification of layers, nodes and inter- and intra-layer edges. A specific model plus a set of operations (for example, removal of irrelevant nodes/edges and layers) defines an exact view of the integrated pathway knowledge given this set of operations. Interfaces to integrate pathway knowledge from standardized encodings into multi-layer pathways and functions for their visualization will be implemented.	de
dc.contributor.coReferee	Waack, Stephan Prof. Dr.
dc.subject.eng	Data integration	de
dc.subject.eng	Multilayer Graph	de
dc.subject.eng	Graph Theory	de
dc.subject.eng	Biological Pathways	de
dc.subject.eng	Leishmaniasis	de
dc.subject.eng	DrugBank	de
dc.subject.eng	UniProt	de
dc.subject.eng	rBiopaxparser	de
dc.subject.eng	BioPAX	de
dc.subject.eng	Knowledge Representation	de
dc.subject.eng	Reproducibility	de
dc.subject.eng	Interoperability	de
dc.subject.eng	Complex Networks	de
dc.identifier.urn	urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-15A6-8-0
dc.affiliation.institute	Fakultät für Mathematik und Informatik	de
dc.subject.gokfull	Informatik (PPN619939052)	de
dc.description.embargoed	2021-03-23
dc.identifier.ppn	1751543757

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