Identifizierung von neuen Komponenten oder Cargoes der COPI Vesikelhüll Maschinerie

Franz, Julia

dc.contributor.advisor	Schwappach-pignataro, Blanche Prof. Dr.
dc.contributor.author	Franz, Julia
dc.date.accessioned	2021-03-26T11:17:45Z
dc.date.available	2021-04-29T09:53:52Z
dc.date.issued	2021-03-26
dc.identifier.uri	http://hdl.handle.net/21.11130/00-1735-0000-0008-57D4-7
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8497
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Identifizierung von neuen Komponenten oder Cargoes der COPI Vesikelhüll Maschinerie	de
dc.type	doctoralThesis	de
dc.title.translated	Identification of new components or cargoes of COPI-coated vesicles	de
dc.contributor.referee	Thumm, Michael Prof. Dr.
dc.date.examination	2021-04-12
dc.description.abstracteng	Within the cell transport vesicles play an essential role in ensuring the functionality of the cell. The heptamere COPI is responsible for transport from the Golgi to the endoplasmic reticulum and also for transport between the cisternae within the Golgi.Studies have shown the dispensability of the μ-homology domain, which is part of delta-COP. Given the thesis that the μ-homology domain is involved in the triad connection, this is a remarkable finding. In order to better understand the fundamental role and current research findings of the μ homology of the delta-COP subunit in eukaryotic systems, a high-content GFP-based localization screening was carried out. The localization of a subset of the yeast proteom enriched with cargoes and machinery components of the vesicular transport was compared with the help of automated microscopy and manual image analysis in a strain with delta-COP with and without μ-homology domain	de
dc.contributor.coReferee	Mausberg, Rainer Prof. Dr.
dc.subject.eng	delta-COPI	de
dc.subject.eng	COPI	de
dc.subject.eng	Coatomer	de
dc.subject.eng	Cargoes	de
dc.subject.eng	Vesicles	de
dc.identifier.urn	urn:nbn:de:gbv:7-21.11130/00-1735-0000-0008-57D4-7-9
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.description.embargoed	2021-04-19
dc.identifier.ppn	1752644034
dc.creator.birthname	Grundmeier	de

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Human- und Zahnmedizin [2870]

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