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dc.contributor.advisor Gruber, Oliver Prof. Dr.
dc.contributor.author Dechent, Aleksandra
dc.date.accessioned 2021-04-06T12:58:26Z
dc.date.available 2021-04-15T00:50:07Z
dc.date.issued 2021-04-06
dc.identifier.uri http://hdl.handle.net/21.11130/00-1735-0000-0008-57DD-E
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 610 de
dc.title Pathophysiologische Veränderungen spezifischer neurofunktioneller Systeme bei Schizophrenie de
dc.type doctoralThesis de
dc.title.translated Pathophysiological Alterations of Specific Neurofunctional Systems in Schizophrenia de
dc.contributor.referee Gruber, Oliver Prof. Dr.
dc.date.examination 2021-04-08
dc.description.abstracteng Schizophrenia is a frequent psychiatric disease with a heterogeneous clinical appearance involving a dysfunction of reward processing. In the present work schizophrenic patients and matched control subjectcs were investigated with functional magnetic resonance imaging while executing an established behavioural paradigm activating the dopaminergic reward system. This paradigm creates a dilemma situation, where a previously conditioned reward stimulus has to be rejected in order to achieve a long-term goal. It thus allows to investigate reward-related brain activation changes depending on the interaction of bottom-up and top-down processes. In the dilemma situation patients showed an increased bottom-up activation of the reward system and a reduced top-down impulse control compared to healthy control subjects. The present work identified neurofunctional alterations in schizophrenic patients and extends the knowledge regarding affected brain areas and their dysfunctions in schizophrenia. de
dc.contributor.coReferee Wilke, Melanie Prof. Dr.
dc.subject.eng Schizophrenia de
dc.subject.eng Functional Magnetic Resonance Imaging de
dc.subject.eng Dilemma Situation de
dc.subject.eng Reward System de
dc.identifier.urn urn:nbn:de:gbv:7-21.11130/00-1735-0000-0008-57DD-E-5
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Psychiatrie (PPN619876344) de
dc.description.embargoed 2021-04-15
dc.identifier.ppn 175321629X
dc.creator.birthname Petrovic de

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