Zur Kurzanzeige

Effekt der Beta-Blocker-Therapie auf die Infektionsrate nach einem ischämischen Schlaganfall

dc.contributor.advisorLiman, Jan Prof. Dr.
dc.contributor.authorBecker, Johannes
dc.date.accessioned2021-04-30T08:35:36Z
dc.date.available2021-05-18T00:50:25Z
dc.date.issued2021-04-30
dc.identifier.urihttp://hdl.handle.net/21.11130/00-1735-0000-0008-580C-9
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-8563
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-8563
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc610de
dc.titleEffekt der Beta-Blocker-Therapie auf die Infektionsrate nach einem ischämischen Schlaganfallde
dc.typedoctoralThesisde
dc.title.translatedInfluence of beta-blocker therapy on the risk of infections in patients with ischemic strokede
dc.contributor.refereeLiman, Jan Prof. Dr.
dc.date.examination2021-05-12
dc.description.abstractengStroke-induced immunodepression is a well characterized complication of acute ischemic stroke. In experimental studies beta-blocker therapy reversed stroke-induced immunodepression, reduced infection rates and mortality. Recent, heterogeneous studies in stroke patients could not provide evidence of a protective effect of beta-blocker therapy. This study investigates the potential preventive effect of beta-blockers in subgroups of patients at high risk for stroke-induced immunodepression. Data from a prospectively derived registry of major stroke patients receiving endovascular therapy between 2011-2017 at the University Medical Center Göttingen was used. The effect of beta-blocker therapy on pneumonia, urinary tract infection, sepsis and mortality was assessed. In this cohort beta-blocker therapy did not reduce the incidence of pneumonia, urinary tract infections, sepsis or mortality. A subgroup of patients with strokes involving the insula and anterio-medial cortex showed an increased risk for pneumonia and sepsis. Patients with right hemispheric stroke had an increased risk for pneumonia. The results support the thesis of certain regions causing a stroke induced immunomodulation. But even in these subgroups beta-blocker therapy showed no significant impact. de
dc.contributor.coRefereeWachter, Rolf Prof. Dr.
dc.subject.engStrokede
dc.subject.engBetablockerde
dc.subject.engImmunodepressionde
dc.subject.engInfectionsde
dc.identifier.urnurn:nbn:de:gbv:7-21.11130/00-1735-0000-0008-580C-9-4
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullMedizin (PPN619874732)de
dc.subject.gokfullNeurologie - Allgemein- und Gesamtdarstellungen (PPN619876247)de
dc.description.embargoed2021-05-18
dc.identifier.ppn175685291X


Dateien

Thumbnail

Das Dokument erscheint in:

Zur Kurzanzeige