dc.contributor.advisor | Liman, Jan Prof. Dr. | |
dc.contributor.author | Becker, Johannes | |
dc.date.accessioned | 2021-04-30T08:35:36Z | |
dc.date.available | 2021-05-18T00:50:25Z | |
dc.date.issued | 2021-04-30 | |
dc.identifier.uri | http://hdl.handle.net/21.11130/00-1735-0000-0008-580C-9 | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-8563 | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-8563 | |
dc.language.iso | deu | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.ddc | 610 | de |
dc.title | Effekt der Beta-Blocker-Therapie auf die Infektionsrate nach einem ischämischen Schlaganfall | de |
dc.type | doctoralThesis | de |
dc.title.translated | Influence of beta-blocker therapy on the risk of infections in patients with ischemic stroke | de |
dc.contributor.referee | Liman, Jan Prof. Dr. | |
dc.date.examination | 2021-05-12 | |
dc.description.abstracteng | Stroke-induced immunodepression is a well characterized complication of acute ischemic stroke. In experimental studies beta-blocker therapy reversed stroke-induced immunodepression, reduced infection rates and mortality. Recent, heterogeneous studies in stroke patients could not provide evidence of a protective effect of beta-blocker therapy. This study investigates the potential preventive effect of beta-blockers in subgroups of patients at high risk for stroke-induced immunodepression.
Data from a prospectively derived registry of major stroke patients receiving endovascular therapy between 2011-2017 at the University Medical Center Göttingen was used. The effect of beta-blocker therapy on pneumonia, urinary tract infection, sepsis and mortality was assessed.
In this cohort beta-blocker therapy did not reduce the incidence of pneumonia, urinary tract infections, sepsis or mortality. A subgroup of patients with strokes involving the insula and anterio-medial cortex showed an increased risk for pneumonia and sepsis. Patients with right hemispheric stroke had an increased risk for pneumonia. The results support the thesis of certain regions causing a stroke induced immunomodulation. But even in these subgroups beta-blocker therapy showed no significant impact. | de |
dc.contributor.coReferee | Wachter, Rolf Prof. Dr. | |
dc.subject.eng | Stroke | de |
dc.subject.eng | Betablocker | de |
dc.subject.eng | Immunodepression | de |
dc.subject.eng | Infections | de |
dc.identifier.urn | urn:nbn:de:gbv:7-21.11130/00-1735-0000-0008-580C-9-4 | |
dc.affiliation.institute | Medizinische Fakultät | de |
dc.subject.gokfull | Medizin (PPN619874732) | de |
dc.subject.gokfull | Neurologie - Allgemein- und Gesamtdarstellungen (PPN619876247) | de |
dc.description.embargoed | 2021-05-18 | |
dc.identifier.ppn | 175685291X | |