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Resource-Economical C–H Activation for Late-Stage Functionalization

dc.contributor.advisorAckermann, Lutz Prof. Dr.
dc.contributor.authorKaplaneris, Nikolaos
dc.titleResource-Economical C–H Activation for Late-Stage Functionalizationde
dc.contributor.refereeAckermann, Lutz Prof. Dr.
dc.description.abstractengOrganic synthesis has traditionally relied on step-, time- and resource-intensive strategies, namely the functional group interconversion and, more recently, on cross-coupling reactions. These approaches have enabled the synthetic community to synthesize every imaginable molecule, given the necessary time and resources. Thus, the next major challenge in the field of organic synthesis is the efficiency, scalability, and sustainability. In this context, transition metal-catalyzed C–H activation has emerged as a powerful tool, as the time- and resource-consuming prefunctionalizations of starting materials are minimized, since inert and omnipresent C–H bonds are utilized as latent functional groups. In this thesis, the primary focus was the development of novel strategies for increasing the molecular complexity of simple precursors via an one-pot difunctionalization approach and the late-stage diversification of peptides. Moreover, in order to address the need for more environmentally-benign C–H transformations we focused on the use of inexpensive Earth-abundant 3d transition metals, namely manganese and
dc.contributor.coRefereeKoszinowski, Konrad Prof. Dr.
dc.contributor.thirdRefereeTietze, Lutz Prof. Dr. Dr. h.c.
dc.contributor.thirdRefereeMata, Ricardo Prof. Dr.
dc.contributor.thirdRefereeJohn, Michael Dr.
dc.contributor.thirdRefereeJanßen-Müller, Daniel Dr.
dc.subject.englate-stage functionalizationde
dc.subject.engmanganese catalysisde
dc.subject.engC–H activationde
dc.affiliation.instituteFakultät für Chemiede
dc.subject.gokfullChemie  (PPN62138352X)de

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