Der Tumorsuppressor p53 reguliert HSF1 im Modell des kolorektalen Karzinoms

The tumor suppressor p53 regulates HSF1 in colorectal carcinoma cells

by Adrian Stender
Doctoral thesis
Date of Examination:2021-07-15
Date of issue:2021-07-13
Advisor:Dr. Ramona Schulz-Heddergott
Referee:Prof. Dr. Matthias Dobbelstein
Referee:Prof. Dr. Jochen Gaedcke
Referee:Prof. Dr. Thomas Meyer
Persistent Address: http://dx.doi.org/10.53846/goediss-8711

 

 

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Abstract

English

The regulator of the cellular stress response programm HSF1 is regulated by the tumor suppressor p53 by inhibition of the phosphorylation of Ser326. This reduces HSF1 transcriptional activity and halts the stress response in human colorectal tumor cells. This is mediated by p53-dependant expression of p21 which inhibits Cyclin-dependant kinases.
Keywords: HSF1; p53
Schlagwörter: HSF1; p53
 
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