Der Tumorsuppressor p53 reguliert HSF1 im Modell des kolorektalen Karzinoms

Stender, Adrian

dc.contributor.advisor	Schulz-Heddergott, Ramona Dr.
dc.contributor.author	Stender, Adrian
dc.date.accessioned	2021-07-13T10:21:31Z
dc.date.available	2021-07-22T00:50:10Z
dc.date.issued	2021-07-13
dc.identifier.uri	http://hdl.handle.net/21.11130/00-1735-0000-0008-58A8-8
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8711
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Der Tumorsuppressor p53 reguliert HSF1 im Modell des kolorektalen Karzinoms	de
dc.type	doctoralThesis	de
dc.title.translated	The tumor suppressor p53 regulates HSF1 in colorectal carcinoma cells	de
dc.contributor.referee	Dobbelstein, Matthias Prof. Dr.
dc.date.examination	2021-07-15
dc.description.abstracteng	The regulator of the cellular stress response programm HSF1 is regulated by the tumor suppressor p53 by inhibition of the phosphorylation of Ser326. This reduces HSF1 transcriptional activity and halts the stress response in human colorectal tumor cells. This is mediated by p53-dependant expression of p21 which inhibits Cyclin-dependant kinases.	de
dc.contributor.coReferee	Gaedcke, Jochen Prof. Dr.
dc.contributor.thirdReferee	Meyer, Thomas Prof. Dr.
dc.subject.ger	HSF1	de
dc.subject.ger	p53	de
dc.subject.eng	HSF1	de
dc.subject.eng	p53	de
dc.identifier.urn	urn:nbn:de:gbv:7-21.11130/00-1735-0000-0008-58A8-8-0
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Pathologie / Pathologische Anatomie / Histopathologie / Zytopathologie - Allgemein- und Gesamtdarstellungen (PPN619875674)	de
dc.description.embargoed	2021-07-22
dc.identifier.ppn	1762841045

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Human- und Zahnmedizin [2872]

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