Direct, indirect and longitudinal immunological effects of anti-CD20 mediated B cell depletion in Multiple Sclerosis

Nissimov, Nitzan

dc.contributor.advisor	Weber, Martin Prof. Dr.
dc.contributor.author	Nissimov, Nitzan
dc.date.accessioned	2021-08-10T08:03:52Z
dc.date.available	2021-08-26T00:50:03Z
dc.date.issued	2021-08-10
dc.identifier.uri	http://hdl.handle.net/21.11130/00-1735-0000-0008-58D7-3
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8779
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Direct, indirect and longitudinal immunological effects of anti-CD20 mediated B cell depletion in Multiple Sclerosis	de
dc.type	doctoralThesis	de
dc.contributor.referee	Lühder, Fred PD Dr.
dc.date.examination	2021-08-19
dc.description.abstracteng	B cell depletion via anti-CD20 antibodies is a highly effective treatment for multiple sclerosis (MS). However, little is known about the maturation/activation stage of the returning B cell population after treatment cessation and the wider effects on other immune cells. In the present study, 15 relapsing-remitting MS patients receiving 1,000 mg of rituximab were included. B, T, and myeloid cells were analyzed before anti-CD20 administration and in different time intervals thereafter over a period of 24 mo. In comparison to the phenotype before anti-CD20 treatment, the reappearing B cell pool revealed a less mature and more activated phenotype: 1) reappearing B cells were significantly enriched in transitional and mature naive phenotypes; 2) the frequency of memory B cells was reduced; and 3) reappearing B cells showed an enhanced expression of activation markers CD25 and CD69, and expressed significantly higher levels of costimulatory CD40 and CD86. T cells showed 1) a persistent increase in naive and 2) a decrease in terminally differentiated subsets.	de
dc.contributor.coReferee	Wienands, Jürgen Prof. Dr.
dc.subject.eng	multiple sclerosis	de
dc.subject.eng	anti-CD20 therapy	de
dc.subject.eng	B cells	de
dc.subject.eng	T cells	de
dc.subject.eng	repletion	de
dc.identifier.urn	urn:nbn:de:gbv:7-21.11130/00-1735-0000-0008-58D7-3-7
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.subject.gokfull	Neurologie - Allgemein- und Gesamtdarstellungen (PPN619876247)	de
dc.subject.gokfull	Neuroanatomie, Neurophysiologie, Neuropathologie (PPN619876255)	de
dc.description.embargoed	2021-08-26
dc.identifier.ppn	1766080383

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