Mitochondriale Dynamik und Funktion in der Muskelentzündung

Mitochondrial dynamics and function in myoinflammation

by Stefanie Susanne Meyer
Doctoral thesis
Date of Examination:2021-10-07
Date of issue:2021-09-30
Advisor:Prof. Dr. Jens Schmidt
Referee:Prof. Dr. Jens Schmidt
Referee:Prof. Dr. Stefan Jakobs
Referee:Prof. Dr. mult. Thomas Meyer
Persistent Address: http://dx.doi.org/10.53846/goediss-8847

 

 

Files in this item

Name:Meyer_Stefanie_Dissertation_Veröffentlichung...pdf
Size:2.64Mb
Format:PDF

The following license files are associated with this item:

Abstract

English

In muscle biopsies of patients with inclusion body myositis signs of degeneration, inflammation and mitochondrial damage can be detected. Pathogenesis of this neuromuscular disorder, predominantly affecting elderly male patients, remains elusive. This research project focuses on the influence of cytokine mediated inflammatory cells stress on mitochondrial dynamics and function in human muscle cells. Data suggests a shift of mitochondrial dynamics towards fission processes, resulting in decreased respiratory chain activity and therefore reduction of ATP production.
Keywords: Mitochondria; Myoinflammation; Inclusion body myositis
 
Statistik