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Prebiotic Synthesis of Inorganic Pyrophosphate (PPi) Driven by a Geochemical Redox Reaction

dc.contributor.advisorDiederichsen, Ulf Prof. Dr.
dc.contributor.authorNasufovska, Atida
dc.date.accessioned2021-10-21T12:27:47Z
dc.date.available2021-10-27T00:50:08Z
dc.date.issued2021-10-21
dc.identifier.urihttp://hdl.handle.net/21.11130/00-1735-0000-0008-5950-A
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-8897
dc.language.isoengde
dc.publisherNiedersächsische Staats- und Universitätsbibliothek Göttingende
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc540de
dc.titlePrebiotic Synthesis of Inorganic Pyrophosphate (PPi) Driven by a Geochemical Redox Reactionde
dc.typedoctoralThesisde
dc.contributor.refereeDiederichsen, Ulf Prof. Dr.
dc.date.examination2021-09-10
dc.description.abstractengIn all extant organisms adenosine triphosphate (ATP) is the energy carrier and transmitter of free energy from exergonic to endergonic processes. Since ATP is a complex molecule, it was unlikely available on prebiotic Earth. Proposed pyrophosphate (PPi) with energy-rich phosphoanhydride bond was considered as plausible energy-source on early Earth. In this thesis, a synthesis of PPi under prebiotic conditions is indicated by condensation of orthophosphate (Pi) in aqueous solution. Furthermore, attempts were made towards synthesizing a peptidic minimal model of the active site A-Cluster in acetyl CoA synthase (ACS), which is a key enzyme in combination with carbon monoxide dehydrogenase (CODH) in ancient WOOD-LJUNGDAHL pathway.de
dc.contributor.coRefereeFritz, Hans-Joachim Prof. Dr.
dc.subject.gerOrigin of Lifede
dc.subject.gerOrigin of Lifede
dc.subject.engPrebiotic Chemistryde
dc.subject.engPrebiotic Chemistryde
dc.identifier.urnurn:nbn:de:gbv:7-21.11130/00-1735-0000-0008-5950-A-5
dc.affiliation.instituteFakultät für Chemiede
dc.subject.gokfullChemie  (PPN62138352X)de
dc.description.embargoed2021-10-27
dc.identifier.ppn1774730138


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