Frakturrisikoevaluation mithilfe verschiedener nationaler und internationaler Risikoscores bei Frauen

National and international osteoporosis fracture evaluation in women

by Anna Giessel
Doctoral thesis
Date of Examination:2021-11-17
Date of issue:2021-11-02
Advisor:Prof. Dr. Heide Siggelkow
Referee:Prof. Dr. Heide Siggelkow
Referee:PD Dr. Daniel Hoffmann
Referee:Prof. Dr. Margarete Schön
Persistent Address: http://dx.doi.org/10.53846/goediss-8903

 

 

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Abstract

English

In the management of osteoporosis the determination of fracture risk is essential for the indication of a specific antiosteoporotic treatment. Within Europe different scores are used for fracture risk prediction. We used the German Guidelines of the Dachverband Osteologie (DVO) and FRAX in the version for Germany as well as not established scores (FRAXendo, DVO+) and compared fracture risks in relation to the actual treatment indication in Germany in women evaluated for osteoporosis. In this retrospective study 555 female patients presenting to the MVZ endokrinologikum Goettingen between July 2007 and June 2014 for evaluation of osteoporosis were investigated. Patient files were analysed for DVO-based 10-year fracture probabilities and for data for the calculation of FRAX-score for major osteoporotic fracture (MOF) and hip fracture (HF). We calculated the DVO Guideline risk score which recommended a specific antiosteoporotic therapy exceeding a 10-year fracture risk of > 30 % and compared the identified patients with those identified by different published thresholds for the FRAX-score (MOF ≥ 14 % resp. ≥ 20 % and HF ≥ 3 %). The study revealed that we treated different women using DVO score and published thresholds for FRAX. Nonetheless in direct comparison there is no significant difference between patients with therapy indication following DVO and FRAX therapy threshold HF ≥ 3 %. In follow up studies the number of incident fractures has to be investigated to evaluate the validity of the different scores for Germany.
Keywords: osteoporosis; bone mineral density; fracture risk; FRAX; DVO; DXA
 
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