| dc.contributor.advisor | Mansur, Ashham Prof. Dr. | |
| dc.contributor.author | Mulwande-Schad, Evelyn | |
| dc.date.accessioned | 2022-01-13T07:45:53Z | |
| dc.date.available | 2022-01-24T00:50:06Z | |
| dc.date.issued | 2022-01-13 | |
| dc.identifier.uri | http://hdl.handle.net/21.11130/00-1735-0000-0008-59E7-0 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-9036 | |
| dc.language.iso | deu | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.ddc | 610 | de |
| dc.title | Einfluss chronischer Erkrankungen auf den Verlauf der Sepsis | de |
| dc.type | doctoralThesis | de |
| dc.title.translated | Impact of chronic medical conditions on the clinical course of sepsis | de |
| dc.contributor.referee | Mansur, Ashham Prof. Dr. | |
| dc.date.examination | 2022-01-17 | |
| dc.description.abstracteng | According to previous studies, the clinical course of sepsis could be affected by preexisting medical
conditions, which are very common among patients with sepsis. This observational study aimed
at investigating whether common chronic medical conditions affect the 90-day mortality risk in
adult Caucasian patients with sepsis. A total of 482 patients with sepsis were enrolled in this study.
The ninety-day mortality was the primary outcome; organ failure was the secondary outcome.
Sepsis-related organ failure assessment (SOFA) scores and the requirements for organ support were
evaluated to assess organ failure. A multivariate Cox regression model for the association between
the 90-day mortality risk and chronic preexisting medical conditions adjusted for all relevant
confounders and mortality predictors revealed the highest hazard ratio for patients with chronic
kidney disease (CKD) (hazard ratio, 2.25; 95% CI, 1.46-3.46; p = 0.0002). Patients with CKD had
higher SOFA scores than patients without CKD (8.9 ± 4.0 and 6.5 ± 3.4, respectively; p < 0.0001).
Additionally, an analysis of organ-specific SOFA scores revealed higher scores in three organ systems
(kidney, cardiovascular and coagulation). Patients with CKD have the highest 90-day mortality risk
compared with patients without CKD or with other chronic medical conditions. | de |
| dc.contributor.coReferee | Sperling, Jens PD Dr. | |
| dc.subject.ger | Sepsis | de |
| dc.subject.ger | Chronische Erkrankungen | de |
| dc.subject.ger | Chronische Niereninsuffizienz | de |
| dc.subject.eng | Sepsis | de |
| dc.subject.eng | Chronic medical conditions | de |
| dc.subject.eng | Chronic kidney disease | de |
| dc.subject.eng | SOFA-Score | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-21.11130/00-1735-0000-0008-59E7-0-5 | |
| dc.affiliation.institute | Medizinische Fakultät | de |
| dc.subject.gokfull | Medizin (PPN619874732) | de |
| dc.description.embargoed | 2022-01-24 | |
| dc.identifier.ppn | 1786028131 | |