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Sensitivität und Spezifität der Detektion von Vasospasmen nach SAB mittels früharterieller CTP-basierten 4D-CTA-Rekonstruktionen sowie konventioneller CTA

dc.contributor.advisorBehme, Daniel PD Dr.
dc.contributor.authorMöller, Cathrin
dc.date.accessioned2022-01-14T10:36:50Z
dc.date.available2022-02-03T00:50:08Z
dc.date.issued2022-01-14
dc.identifier.urihttp://hdl.handle.net/21.11130/00-1735-0000-0008-59F1-4
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-9042
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc610de
dc.titleSensitivität und Spezifität der Detektion von Vasospasmen nach SAB mittels früharterieller CTP-basierten 4D-CTA-Rekonstruktionen sowie konventioneller CTAde
dc.typedoctoralThesisde
dc.title.translatedSensitivity and Specificity of the Detection of Vasospasm after SAH by CTP-based 4D-CTA-Reconstruction and conventional CTAde
dc.contributor.refereeBehme, Daniel PD Dr.
dc.date.examination2022-01-26
dc.description.abstractengCerebral vasospasm frequently occur after aneurysmal subarachnoid hemorrhage (aSAH) and are a major contributor to mortality and morbidity following aSAH. Their diagnosis is a challenge which comes with a significant radiation exposure due to repeated CTA and CTP scans. In this work, I investigate the diagnostic performance of 4D-CTA reconstructed from the CTP dataset in relation to conventional CTA. I performed a retroscpective analysis of patients with aSAH who received endovascular intervention as a rescue treatment for vasospam. Considering digital subtraction angiography as gold standard, I estimated sensitivity, specificity, and interrater reliability for 4D-CTA and conventional CTA. I found no evidence that early-phase 4D-CTA performs significantly worse than conventional CTA by any characterization, and in many cases performs significantly better. This study suggests that CTA scans could be replaced by 4D-CTA reconstructed from the CTP dataset, thereby reducing radiation exposure.de
dc.contributor.coRefereeMielke, Dorothee Prof. Dr.
dc.subject.engSAHde
dc.subject.engvasospasmde
dc.subject.engCTAde
dc.subject.engCTPde
dc.identifier.urnurn:nbn:de:gbv:7-21.11130/00-1735-0000-0008-59F1-4-8
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullNeurologische Diagnostik, Neuroradiologie (PPN619876263)de
dc.subject.gokfullMedizinde
dc.description.embargoed2022-02-03
dc.identifier.ppn178619712X


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