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Zur Gentoxizität von Nitromoschus im Schwesterchromatidaustausch-Test und im Mikrokern-Test

Gentoxicity of nitro musks in the sister-chromatid-exchange-test and in the micronucleus test

by Antonia Komischke
Doctoral thesis
Date of Examination:2011-06-22
Date of issue:2011-06-22
Advisor:Prof. Dr. Hartmut Dunkelberg
Referee:Prof. Dr. Hartmut Dunkelberg
Referee:Prof. Dr. Ernst Hallier
Persistent Address: http://hdl.handle.net/11858/00-1735-0000-0006-B1FC-A

 

 

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Abstract

English

The nitro musk compounds musk ambrette, musk xylene, musk ketone, musk moskene and musk tibetene were tested for their genotoxicity activity in the sister-chromatid exchange test with human lymphocytes in vitro in the presence and the absence of an exogenous metabolising system from rat liver S9-mix and in the micronucleus test with human lymphocytes in vitro and the human hepatoma cell line HepG2. Nitro musks revealed no genotoxicity in the sister-chromatid exchange test and in the micronucleus test.
Keywords: nitro musks; genotoxicity; sister-chromtid exchange test; micronucleus test; human lymphocytes; HepG2

Other Languages

Die Nitromoschussubstanzen Moschus Ambrette, Moschus Xylol, Moschus Keton, Moschus Mosken und Moschus Tibeten wurden im Schwesterchromatidaustausch-Test mit Humanlymphozyten in vitro mit und ohne metabolisierendes System S9-Mix, einem Rattenleberextrakt, sowie im Mikrokern-Test mit Humanlymphozyten in vitro und metabolisch aktiven Hepatozyten HepG2 auf ihre Gentoxizität untersucht. Nitromoschussubstanzen hatten keine gentoxische Wirkung im Schwesterchromatidaustausch-Test und im Mikrokern-Test.
Schlagwörter: Nitromoschus; Gentoxizität; Schwesterchromatidaustausch-Test; Mikrokern-Test; Humanlymphozyten; HepG2
 

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