Medizin
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Human- und Zahnmedizin [2494]
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Molekulare Medizin [199]
Recent Submissions
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Intranasale Medikamentenapplikation zur Akutschmerztherapie und Analgosedierung bei Kindern – Implementierung und Anwendungsbeobachtung der Methode
(2022-07-01)In an event of injuries or urgent interventions, children require adequate analgesia or analgosedation, which they are often denied. This results not least from technical challenges, such as the difficult and possibly ... -
Studying the role of coenzyme Q10 in mitochondrial calcium and redox signaling
(2022-06-30)Mitochondria can take up large amounts of calcium (Ca2+) in order to control the activity of several enzymes and their bioenergetics output. As a consequence of this metabolic flux, reactive oxygen species (ROS) are generated ... -
Einfluss von prä-analytischen Entnahme- und Lagerungsbedingungen auf die Stabilität und Konzentration von Amyloid-ß-Peptiden in Blut
(2022-06-29)In an increasingly aging population, age-related diseases such as dementia play a central role. Expecting an increase of the number of patients suffering from dementia worldwide, dementia-related research is becoming more ... -
Einfluss des intraoperativen Volumenmanagements auf das Outcome von Tumorresektionen im Mund-, Kiefer- und Gesichtsbereich mit plastischer Rekonstruktion mittels freier, mikrovaskulärer Lappenplastik
(2022-06-27)Free flap surgeries for the reconstruction of orofacial defects following head and neck cancer resections are generally considered to be proven procedures with high success rates. Perioperative hemodynamic management seems ... -
Structure and molecular function of WD-40 repeat-containing autophagy proteins Atg18, Atg21 and Hsv2
(2022-06-23)Autophagy is a highly regulated cellular degradation and recycling process conserved from yeast to higher eukaryotes. This process is constitutively active at a low level, and non-selectively degrades portions of the cytosol ... -
Retrospektive Analyse von an der Universitätsmedizin Göttingen (UMG) behandelten Patienten und Patientinnen mit kolorektalen Karzinomen im Zeitraum 2000 bis 2020 und Korrelation der klinischen Parameter mit Proteinanalysen
(2022-06-23)Background: In regard of the Warburg-effect and the progressively more personalised therapy and prognostic options available, based on molecular biology research, the EGFR- and Glycolysis receptor proteins present an ever ... -
Der Einfluss rekombinanter Neuroligine auf die neuronale Reifung
(2022-06-21)Neuroligins are a group of postsynaptic adhesion molecules associated with formation, maturation and function of neuronal synapses. Additionally, some isoforms have been connected to autism spectrum disorders. Neuroligin ... -
Effect of CLN3-loss-of-function on cellular metabolism and signalling
(2022-06-20)Since a coordinated function of all organelles is essential for the proper health of a eukaryotic cell, a defect in a single organelle can affect the condition of other organelles. For instance, mitochondrial dysfunction ... -
The role of SFRP5 in cardiomyocyte function
(2022-06-17)Heart failure is one of the most common cause of death in Germany. The current treatment options are known to decelerate disease progression, but it cannot be halted or reversed. To date, the underlying molecular mechanisms ... -
Wirkung von Ostarine – ein selektiver Androgenrezeptormodulator (SARM) – auf das osteoporotische Femur der orchiektomierten Ratte
(2022-06-17)In this work, the drug ostarine, a selective androgen receptor modulator, was examined for its effectiveness in treating the osteoporotic femur of an orchiectomized rat. In the proximal femur, Testosteron Therapy improved ... -
Eine Untersuchung der Bedeutung des Apoptose-induzierenden Faktors am podozytären Zelltod
(2022-06-17)In this work, the involvement of apoptosis-inducing factor (AIF) in podocyte cell death was investigated in vitro using an established podocyte cell line. For this purpose, a model was used in which the three different ... -
Expressionsverhalten von ABC-A3 in Nicht-kleinzelligen Bronchialkarzinomen - ein neoadjuvantes Therapiekonzept
(2022-06-17)ATP-binding cassette transporter protein ABCA3 is known to be responsible for drug resistance. This respectively study examined the expression of ABCA3 as a possible predictive marker for a response to chemotherapy. The ... -
Wirkung von Baicalein auf die Lendenwirbelsäule der osteoporotischen Ratte
(2022-06-15)The goal of this study is to investigate the impact varying degrees of doses of Baicalein have on the Lumbar Spine of an ovariectomized rat. Therefore, 60 at the time of the ovariectomy three-month-old Sprague-Dawley-Rats ... -
Zur Rolle des homodimeren Erythropoietin-Rezeptors für erythropoietininduzierte Neurogenese und kognitive Funktionen im Mausmodell
(2022-06-13)Cognitive dysfunction and decline are clinical hallmarks of neurodegenerative brain diseases and yet await sufficient therapy. Proven in numerous clinical studies, erythropoietin, named after its function in stimulating ... -
Differenzierungspotenzial humaner primärer Parodontalligament-Zellen von Patienten mit gesundem Zahnhalteapparat
(2022-06-07)The fibrous apparatus of the human periodontium is subject to both structural aging processes and adaptation to functional loads and thus exhibits characteristics of a dynamic system. Structural studies of the parodontal ... -
Effektivität des differenziellen Lernens im Rahmen der Mundhygieneinstruktion bei Grundschülern
(2022-06-03)Aim: The aim of the present study was to investigate the influence of tooth brushing training using the differential learning approach on plaque and gingivitis reduction in primary school children and to compare it with ... -
Immunhistochemische Untersuchung von Patienten mit Bisphosphonat-assoziierten Osteonekrosen der Kiefer
(2022-06-03)The aim of this present study was to compare resected mandibula bone segments of patients with bisphosphonate-related osteonecrosis of the jaw (BRONJ) to healthy mandibula bone samples with reference to histological ... -
Erfahrung des Operateurs als Einflussfaktor auf die Operationsdauer am Beispiel ausgewählter unfallchirurgischer und orthopädischer Eingriffe an einer Universitätsklinik
(2022-06-03)In healthcare, cost-effectiveness plays an increasingly important role, at least since the introduction of the Diagnosis Related Groups (DRG) system. Meanwhile, the training and further education of residents gets more ... -
Cancer cell death by mitotic failure upon combined kinase inhibition
(2022-06-02)Cancer cells are prone to replicative stress to a greater extent than healthy cells are. Thus, replicative stress might be a way to target cancer cells in a more specific way than conventional chemotherapeutics do. According ... -
Ergebnisse der Behandlung retinaler Erkrankungen mit Makulaödem anhand des modifizierten Treat & Extend-Schemas im 3er-Block. Retrospektive Analyse aus der täglichen klinischen Anwendung. 1. Chorioidale Neovaskularisation im Rahmen einer altersabhängigen Makuladegeneration (AMD) 2. Diabetisches Makulaödem 3. Makulaödem nach retinalem Venenverschluss
(2022-05-31)Background. As part of intravitreal operative medication injections (IVOM) in the therapy of diseases with macular edema patients receive also associated frequent check-ups, which altogether causes treatment discontinuitations ...