Medizin
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Human- und Zahnmedizin [3202]
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Molekulare Medizin [262]
Recent Submissions
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Prognostische Bedeutung von hochsensitivem Troponin I bei normotensiven Patienten mit akuter Lungenembolie
(2025-04-17)This study investigated the prognostic significance of high-sensitivity troponin I (hsTnI) in normotensive patients with acute pulmonary embolism (PE). The goal was to identify an optimized cutoff value for hsTnI for risk ... -
Einfluss von Elektrolytkonzentrationen auf Qualitätsparameter bei Elektrokonvulsionstherapie
(2025-04-14)The effectiveness of electroconvulsive therapy depends on achieving a generalized seizure. Several strategies exist on how to improve seizure quality. From clinical observations we know that electrolyte disturbances often ... -
Evaluation der Behandlung mit KAN0438757 in Kombination mit verschiedenen Chemotherapien im glykolytischen und lipogenen Subtyp des duktalen Pankreaskarzinoms
(2025-04-14)Despite current treatment options, the 5-year survival rate for patients with pancreatic ductal adenocarcinoma is below 10%. This highlights the relevance of new therapeutic approaches. Pancreatic ductal adenocarcinoma, ... -
Zur Bedeutung von Typ-D-Persönlichkeit und Bindungsstil bei Patient*innen mit kardiovaskulären Risikofaktoren oder Herzinsuffizienz aus der Diast-CHF-Studie
(2025-04-14)OBJECTIVE: Although the prevalence of depression, anxiety and vital exhaustion in cardiac patients is high and can contribute to the deterioration of their health, mental disorders are often underdiagnosed and inadequately ... -
In-vivo-Diagnostik und Therapiemonitoring mittels 18F-FDG-Positronenemissionstomographie im Tg4-42 Alzheimer-Mausmodell
(2025-04-14)In this study, two groups of Alzheimer's model mice of the Tg4-42 type were injected intravenously with 18F-FDG at the age of 7 months and 3 months. Subsequently, the 18F-FDG uptake of the brain was visualized by PET/MRI. ... -
Der Einfluss von 8-Prenylnaringenin und Alendronat in Kombination mit vertikaler Ganzkörpervibration auf den Wirbelkörper des osteopenischen Rattenmodells
(2025-04-14)Osteoporosis is a systemic disease of the skeleton with reduced bone stability and increased fracture risk. Due to rising osteoporosis-related healthcare costs, the disease and its treatment represent an increasing health ... -
Gesundheitsbezogene Lebensqualität von Kindern nach Schädel-Hirn-Trauma: Vergleich der Kinder- und Elternperspektive
(2025-04-14)Pediatric Health-Related Quality of Life (HRQoL) as a measure of subjective well-being and functional capacity has gained increasing importance in recent years. However, the HRQoL of children and adolescents following a ... -
Charakterisierung der LIFR/STAT3-Inhibition in der Therapie ARID1A-defizienter Pankreaskarzinome
(2025-04-14)Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignant tumors and is expected to be the second most common cause of cancer-associated death after lung cancer by 2030. A major reason for the poor ... -
Mechanismen der Tachykardie-induzierten Kardiomyopathie im humanen Myokard und Kardiomyozyten
(2025-04-14)Tachycardia-induced cardiomyopathy (TCM) describes a reversible form of left-ventricular dysfunction based on a persisting tachycardia. Its clinical impact is relevant but often underestimated, hence its mechanisms remain ... -
The Role of Clonal Evolution and Anti- Apoptotic Dependencies in Cancer Progression and Therapy Resistance: Implications for Personalized Medicine
(2025-04-10)Cancer is characterized by significant heterogeneity, both across and within individual tumors, posing challenges for treatment. This thesis investigates clonal evolution (CE) and its association with apoptotic mechanisms ... -
Die einwärtsgleichrichtenden Kaliumströme IK1 und IK,ACh in atrialen Kardiomyozyten aus humanen induzierten pluripotenten Stammzellen und ihr Remodelling unter in-vitro Feldstimulation
(2025-04-09)Atrial fibrillation is the most common sustained supraventricular arrhythmia in humans and is associated with an immense increase in the risk of stroke. Many key questions about the development and therefore also the ... -
Differenzierung histologischer Subtypen des Nierenzellkarzinoms anhand multiphasischer CT: Eine Radiomics und Machine Learning Studie
(2025-04-08)The number of renal cell carcinoma (RCC) diagnoses has increased since the late 1990s, primarily due to incidental findings. Early detection complicates the radiological differentiation of the three most common RCC ... -
Faktoren, die Studierende im Praktischen Jahr bei der zukünftigen Facharztwahl beeinflussen
(2025-04-08)The following dissertation shows factors that influence students in choosing their future specialty in medicine. Qualitative content analysis can be chosen as a form of analysis of interviews. Referring to the elaborated ... -
The Functional Role of the Membrane Bending Ability of the Yeast PROPPINs
(2025-04-04)The meticulously regulated mechanism, which overseas processes of cellular breakdown and recycling, is called macroautophagy. It has been preserved from yeast to more advanced eukaryotic organisms. As a response to various ... -
Antibody-mediated recognition of central nervous system antigen as therapeutic target
(2025-04-04)The discovery of autoantibodies directed against myelin oligodendrocyte glycoprotein (MOG) in a proportion of patients diagnosed with multiple sclerosis (MS) led to the definition of MOG antibody-associated disease (MOGAD) ... -
Mechanisms of T-cell mediated inflammatory neurodegeneration
(2025-04-04)Multiple sclerosis (MS) is a T-cell mediated, chronic, demyelinating disease of the central nervous system (CNS). Neurodegeneration and axonal loss are associated with increased disability and disease progression. ... -
Die Wirksamkeit eines 6-wöchigen hochfrequenten, standardisierten Sportprogramms auf die Erkrankungsschwere in drei Gruppen psychiatrischer Störungen
(2025-04-03)Depression, addiction syndromes and schizophrenia are three of the most common severe psychiatric disorders. For all three disorders, there are established treatment regimes and guidelines for diagnosis and treatment. The ... -
Quantitative T1-Kartierung des Cerebrums und quantitative Liquor-Flussmessungen bei Patienten mit idiopathischem Normaldruckhydrozephalus und Idiopathischer Intrakranieller Hypertension
(2025-04-03)Idiopathic normal pressure hydrocephalus (iNPH) and idiopathic intracranial hypertension (IIH) are important cerebral disorders with impaired production, circulation or resorption of cerebrospinal fluid (CSF). Despite ... -
Molekulargenetische Charakterisierung syndromaler, genetischer Erkrankungen mittels Next-Generation-Sequencing
(2025-04-03)Rare diseases form a heterogeneous group of diseases that encompass a broad clinical spec-trum with a large variety of clinical features and characteristics. In the European Union, a disease is considered rare if it affects ... -
Die Rolle von OPN5 als UV-Licht-sensitiver G-Protein gekoppelter Rezeptor in Melanozyten
(2025-04-02)The UV-A component (~380 nm) of sunlight leads to the pigmentation of the skin, which temporarily protects it from sunburn and DNA damage, and over the long term prevents the development of tumors, such as malignant ...