Medizin
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Human- und Zahnmedizin [2770]
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Molekulare Medizin [228]
Recent Submissions
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Der Einfluss von Δ9-Tetrahydrocannabinol und Cannabidiol auf die Pathologie des Morbus Alzheimer im Tg4-42hom-Mausmodell
(2023-09-29)This thesis evaluates the histopathological effects of a long-term application of Cannabidiol and delta-Tetrahydrocannabiol in a mouse model of the sporadic Alzheimer`s disease in a preventive and therapeutic approach ... -
Physical activity and developmental psychopathology in children and adolescents: cross-sectional, longitudinal follow-up and concurrent developmental relationships
(2023-09-26)The current cumulative dissertation aimed to investigate the cross-sectional and longitudinal relationships between mental health problems, including symptoms of ADHD, and physical activity (PA) in children and adolescents. ... -
Retrospektiver und prospektiver Vergleich der klinischen Performance des CertasPlus- mit dem proGAV 2.0-Shuntventil zur Behandlung von Hydrocephalus-Patienten
(2023-09-25)Implantation of a vp-shunt represents the current standard of care in hydrocephalus patients. Both combination valves implanted in this study contain a proprietary differential pressure valve, which is combined with a ... -
Natriuretische Peptide und paroxysmales Vorhofflimmern bei Patienten mit ischämischem Schlaganfall
(2023-09-25)The detection of paroxysmal atrial fibrillation (pAF) is of central clinical interest in the treatment of stroke patients, as the initiation of sufficient secondary prophylaxis can significantly reduce the risk of recurrent ... -
Evaluation of synergistic hybrid nanoparticles for improved diagnosis and treatment of pancreatic cancer
(2023-09-13)Pancreatic ductal adenocarcinoma (PDAC) has a devastating prognosis with no effective treatment options. Several factors contribute to its lethality, including the usually late diagnosis in the already advanced stage and ... -
Ehrenamtliche Begleitung von Menschen mit einer nicht-onkologischen Erkrankung am Lebensende
(2023-09-13)Background: Hospice volunteers are important actors in hospice and palliative care. Due to the progressive integration of non-oncological patients, they will be supported more and more by volunteers in the future. The aim ... -
Validierung der nicht-mydriatischen Funduskamera „Cobra“ als Screeningverfahren zur Erkennung von diabetischer Retinopathie bei Patienten mit Diabetes mellitus in der Diabetesambulanz der Universitätsmedizin Göttingen
(2023-09-13)Purpose: Retinopathy screening as part of regular preventive examinations may contribute to better care of diabetic patients. In the diabetes outpatient clinic of the University Medical Center Göttingen, we investigated ... -
Einfluss der Herzinsuffizienz auf das Outcome nach Thrombektomie bei Schlaganfallpatienten
(2023-09-12)There are studies that indicate that heart failure has an impact on the mortality and morbidity of stroke patients. But this influence of heart failure on stroke outcome has not yet been established. We asked ourselves to ... -
Bedeutung von Elaboration und Kontrastierung von Falschantworten für die Entwicklung differentialdiagnostischer und -therapeutischer Entscheidungskompetenz im Medizinstudium
(2023-09-12)One of the main learning objectives during medical studies and training is the acquisition of clinial reasoning skills, enabling accurate diagnostic and therapeutic decision-making in clinical settings. A proven way to ... -
Evaluation der Gewebeperfusion des mikrozirkulären Systems mit Hilfe von hyperspektraler Bildgebung nach Majoramputation an der unteren Extremität
(2023-09-11)Introduction: Perfusion disorders are a frequent complication after major amputation at the lower limb. The resulting decreased tissue perfusion and venous stasis lead to wound healing disorders and tissue necrosis as well ... -
In vitro analyses of CD4-protein function in dedifferentiated keratinocyte cell lines
(2023-09-06)To study the role of the Hedgehog-Patched (Hh/Ptch) signaling pathway in T-cells, the two-step DMBA/TPA carcinogenesis protocol have been applied to mice with an homozygous Ptch depletion in CD4-expressing cell (Ptch ... -
Charakterisierung der Auswirkung des Alters auf die Histopathologie der Multiplen Sklerose
(2023-09-05)In this thesis, we analysed the impact of age on the histopathology of multiple sclerosis. For this, we examined tissue sections of brain biopsies of MS-patients, 28 belonging to late onset multiple sclerosis (age ≥ 50 ... -
Hungernder Krebs-Evaluation der Kombinationstherapie mit 2-Deoxy-D-Glukose und Metformin beim Endometriumkarzinom
(2023-09-04)In this thesis, several aspects of the tumor metabolism were examined as an approach for antiproliferative therapies. Thereby, it is shown that therapy with metformin and 2-Deoxy-D-Glucose reaches a significant decrease ... -
Evaluation of the antifibrotic potential of Serelaxin in two experimental models of cardiac fibrogenesis
(2023-08-28)This study is based on the finding that Relaxin was identified in Rln1 gene knockout mice as a naturally occurring regulator of collagen turnover in the heart (Du et al. 2003). Additionally, in a model of spontaneously ... -
EEG network analyses in patients with genetic generalized epilepsy
(2023-08-24)Genetic generalized epilepsy (GGE) accounts for about 15% of all epilepsies (Jallon & Latour, 2005). Its etiology remains unknown and molecular processes have only partly been understood. In the clinical field patients ... -
Einflüsse und Prädiktoren auf die (Früh-)Kontinenz nach radikaler robotisch-assistierter laparoskopischer Prostatektomie
(2023-08-24)In the cases of locally limited and locally advanced, non-metastatic prostate cancer, surgical removal of the prostate is a primary therapeutic option, which is increasingly performed as robot-assisted laparoscopic radical ... -
Einfluss psychosomatischer Parameter auf die Lebensqualität von Patienten mit diastolischer Herzinsuffizienz im Rahmen der Aldo-DHF-Studie
(2023-08-23)The aim of the present work was to find physical, somatic, psychological, socioeconomic, and interpersonal parameters at baseline that predict physical, mental, and overall health-related quality of life, as well as anxiety ... -
Inkongruente Bedürfnisbefriedigung bei Suchterkrankten: Ein Vergleich von Menschen mit Alkohol --, Medikamenten und Verhaltenssucht mit gesunden Probanden
(2023-08-22)Both motivational incongruence (INK-G) and depression have been shown to be associated with alcohol dependence and as such a possible target for treatment strategies. Non-substance addictions (NSA) like Internet addiction ... -
High throughput strategies for electrophysiological characterisation of cardiomyocytes
(2023-08-22)Personalised medicine describes the customised application of medical treatment at a patient-specific level. This type of precision medicine stratifies patients based on their specific genotype or phenotype for targeted ... -
Der Einfluss von Cannabidiol auf die Alzheimer Pathologie im 5xFAD Mausmodell in einem präventiven Behandlungsansatz
(2023-08-22)This work examines the neurohistological effects of chronic treatment with cannabidiol on pathologies typical of Alzheimer's disease in the cortex and hippocampus of the 5xFAD mouse model. These include accumulation of ...