Medizin
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Human- und Zahnmedizin [2581]
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Molekulare Medizin [208]
Recent Submissions
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WIN-55,212-2-Therapie in einem Modell für die sporadische Alzheimer Erkrankung
(2022-11-29)With its far-reaching influence on neuroprotection and inflammation, the endocannabinoid system (ECS) is a promising approach for the therapy of Alzheimer's disease (AD). WIN-55,212-2 (WIN) is a synthetic cannabinoid and ... -
Etablierung der Methoden zur Messung des Metallabriebs von flexiblen Titan-Langzeitimplantaten bei Kindern mit Wirbelsäulendeformitäten
(2022-11-29)In the present work, different methods for measuring metal wear of flexible, growth-friendly titanium long-term implants in children with spinal deformities were investigated. It is known that titanium wear of implants can ... -
Oxidative stress in the pathogenesis of renal injury: the effect of the antioxidant danshensu on renal fibrosis
(2022-11-29)Chronic kidney disease (CKD), often manifested in its end-stage as renal fibrosis, is a widespread illness, for example in children following congenital urinary obstruction and in adults due to an increasing number of ... -
Das Ausmaß der Fibrose beim duktalen Pankreaskopfkarzinom korreliert mit der Prognose
(2022-11-29)Extension of fibrosis correlates with the prognosis for pancreatic ductal adenocarcinoma (PDA) Müller J, Kitz J, Bernhard M, Azizian A, Grade M, Ströbel P, Ghadimi M, Gaedcke J. Introduction For patients with PDA ... -
Epidemiologischer Vergleich und Analyse der operativen Versorgung von Patienten mit Lippen-, Kiefer-, Gaumenspalten - eine Mono-Center Analyse
(2022-11-29)From 2001 to 2019 404 patients with orofacial clefts have visited the clinic for maxillofacial surgery in Göttingen. An increasement of case numbers has shown during this period, even higher in male patients. The gender ... -
Einfluss der Gabe von Katecholaminen bei Mund-Kiefer-Gesichtschirurgischen Lappenplastiken nach Tumorresektion
(2022-11-28)Tumor resection followed by a free flap is a common therapy for oral and maxillofacial tumors. One of the most common serious complications of flap transplantation is insufficient perfusion of the transplanted tissue, which ... -
The impact of expectation on patient-rated global effectiveness of total hip arthroplasty
(2022-11-28)Total Hip Arthroplasty (THA) is a standard elective surgery for hip osteoarthritis when reaching the limits of conservative medicine. Patient-based assessments are increasingly used for quality judgment after medical ... -
Psychosoziale Auswirkungen nach konservativer oder operativer Versorgung von Knochenfrakturen im Kindes- und Jugendalter
(2022-11-28)In the 70s and 80s of the last century, fractures in children and adolescents were treated approximately 90% conservatively and 10% surgically. Due to improvements in anesthesia and surgical methods, surgical therapy has ... -
Zeitbedarf für die präklinische Ganzkörperimmobilisation bei Schwerverletzten
(2022-11-24)Background: Spinal stabilisation is recommended for prehospital trauma treatment. In Germany, vacuum mattresses are traditionally used for spinal stabilisation, whereas in anglo-american countries, long spine boards are ... -
Semiquantitative Evaluation der myokardialen Perfusion bei Patienten nach Myokardinfarkt und intramyokardialer Stammzelltherapie
(2022-11-22)Semiquantitative evaluation of the myocardial perfusion by patients after myocardial infarction and myocardial bone marrow CD133+ stem-cell transplantation by MRI. Post-infarction patients with chronic ischemia and reduced ... -
Nephrotoxizität bei immunsuppressiver Therapie nach Lebertransplantation Ein systematischer Review und Metaanalyse
(2022-11-22)It is known that calcineurin inhibitors (CNI), tacrolimus and cyclosporine have acute and chronic nephrotoxic effects. Liver transplant recipients get CNI after transplantation. Therefore, are used to spare CNI other ... -
Morphometrische Wirbelkörperveränderungen bei Kindern mit spinaler Muskelatrophie und bilateralen vertikal-expandierbaren Wirbelsäulenimplantaten
(2022-11-22)Treatment of progressive spinal deformities in children and adolescent with vertical expandable spinal implants can often avoid early spinal fusion with adverse effects on thoracic and lung development during the growth ... -
Amputationen der unteren Extremität: Postoperativer Verlauf und Analyse der Versorgungsabläufe
(2022-11-22)Revisions occur 25% to 40% after lower extremity amputation. Some factors increase the risk of revision and are associated with it. The aim of the study was therefore to determine which factors might be associated with ... -
Auswirkungen minderperfundierter Lungenareale und Beatmungsschäden auf die elektrische Impedanz von Lungengewebe
(2022-11-18)The effects of hypo perfused lung areas and ventilator-induced injury on the electrical impedance of lung tissue were investigated. Electrical impedance tomography (EIT) was applied to visualize impedance profiles. Targeted ... -
Image analysis of immunohistochemistry-based biomarkers in breast cancer
(2022-11-18)Breast cancer is the leading form of cancer in women in Germany with about 69.000 new cases anually and a lifetime risk of 12.9%. One in eight women will develop a malignant neoplasm of the breast. Early diagnosis measures ... -
In vivo application of CRISPR/Cas9 mediated gene re-expression in the failing mouse and human myocardium
(2022-11-17)Transcriptional adaptation in cardiomyocytes precedes cellular deterioration and functional decline upon myocardial stress and damage resulting in heart failure progression. The re-activation of WNT/β-catenin (CTNNB1) ... -
Einfluss einer fettreichen Ernährung auf eine funktionelle Einzelniere mit den Risiko-Genvarianten COL4A3 +/- und NPHS +/R140Q im Mausmodell
(2022-11-17)Alport syndrome is a hereditary nephritis that leads to ESRD in those affected between the ages of 20 and 30. The only long-term treatment option is a kidney transplantation. Since the waiting time for a kidney donation ... -
Osteoporose bei systemischer Mastozytose: Eine Kohortenstude mit 43 Patienten
(2022-11-16)Introduction Mastocytosis is a group of rare diseases with a clonal proliferation of mast cells in one or more organs. Systemic mastocytosis has been described as the second most frequent cause of secondary osteoporosis ... -
Nanoskalauntersuchungen vom zellulären Metabolismus mittels Sekundärionen-Massenspektrometrie
(2022-11-15)Alzheimer is the most neurodegenerative disease. Hallmark of Alzheimer’s disease ist he pathological accumulation of the proteins Aβ and Tau. The aggregates of these accumulation are called Aβ-plaques and neurofibrillary ... -
Diagnostische Vergleichbarkeit der kardialen Troponine I und T
(2022-11-14)Cardiac troponins are crucial for the diagnosis of acute myocardial infarction. Despite known differences in their diagnostic implication, there are no recommendations for only one of the two troponins, cardiac troponin I ...