Medizin
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Human- und Zahnmedizin [2664]
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Molekulare Medizin [217]
Recent Submissions
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Entwicklung von Nierenfunktion und Nierenschädigung bei Patienten mit Alport-Syndrom in Abhängigkeit des Beginns einer nephroprotektiven Therapie
(2023-03-28)Alport syndrome is a hereditary collagen type IV disease which affects kidneys, eyes and hearing. The extent of kidney involvement is prognostically relevant; if left untreated, terminal kidney failure can occur at an early ... -
Expressionsmuster von EBV mikroRNAs in Hodgkin Lymphomen
(2023-03-24)Epstein-Barr virus encodes 40 different miRNAs with considerable impact on cellular functions of the latently infected cell. In this study EBV miRNA expression patterns in EBV-positive Hodgkin lymphoma and other malignant ... -
Identification of biomarker-defined populations in precision medicine
(2023-03-24)The aim of precision medicine is to identify the treatment that provides the best response for a patient. For this purpose, predictive biomarkers play a crucial role. Due to their ability to define subgroups of patients ... -
Cardiac fibroblast phenotype regulation in engineered connective tissues with a special focus on ER adaptation and stress
(2023-03-23)Cardiovascular diseases cause adverse myocardial remodeling due to cardiomyocyte loss and modifications to the extracellular matrix (ECM), which can ultimately lead to contractile dysfunction and pathological cardiac ... -
Expression of gemcitabine metabolizing enzymes in different pancreatic cancer model systems
(2023-03-23)Pancreatic cancer still exhibits a dismal five-year overall survival rate of 9 % and is foreseen to even increase in incidence and mortality rates in the future. This is due to unspecific symptoms leading to late diagnosis, ... -
Identifizierung von In-vivo Interaktionspartnern von PMP22 im peripheren Nerven der Ratte
(2023-03-20)The most common hereditary neuropathy, Charcot-Marie-Tooth disease type 1A (CMT1A), is caused by a duplication of the gene coding for the peripheral myelin protein 22 (PMP22). Despite long lasting scientific investigations, ... -
Radiologische Bildgebung bei Primären Sarkomen der Niere: eine multizentrische Studie
(2023-03-17)Primary renal sarcomas are very rare renal malignancies of mesenchymal origin which comprise a variety of histological subtypes. They belong to the heterogeneous group of soft tissue sarcomas which can occur in variable ... -
Insuffizienzfrakturen des Sakrums-operative Versorgung durch minimalinvasive dorsale winkelstabile Plattenosteosynthese
(2023-03-14)Fragility fractures of the pelvis are common in older patients, We evaluated the clinical outcome of 53 patients which were treated surgically using a minimally invasive posterior locked compression plate (MIPLCP). Data ... -
Beeinflusst der knockdown des membranständigen Östrogenrezeptors GPER (GPR30) die anti-invasive Wirksamkeit selektiver Östrogenrezeptor beta (ERb)-Agonisten?
(2023-03-13)The aim of the present work was to investigate to what extent suppression of GPER1 affects viability and invasiveness of TNBC cells. In addition, it was of interest to determine whether suppression of GPER1 affects the ... -
Therapie der Hyperbilirubinämie bei Patienten mit einem Pankreaskarzinom
(2023-03-13)Approximately 18,000 patients are diagnosed with pancreatic cancer in Germany each year. Unfortunately, prognosis is still quite poor. The only curative therapy is a surgical resection of the tumor, however only about ... -
Retrospektive Bewertung des kindlichen Traumas bei depressiven PatientInnen
(2023-03-13)This study investigates the potential influence of treated depression on retrospective assessments of childhood trauma in unipolar and bipolar depressed subjects, using the Childhood-Trauma-Questionnaire (CTQ) and ... -
Behavioral and electrophysiological assessment of hearing function in mice with deficient sound encoding at inner hair cell ribbon synapse
(2023-03-10)Auditory synaptopathy in humans is characterized by poor speech perception especially in noisy environments despite of preserved active cochlear amplification. The ABR of affected patients is absent or shows a significant ... -
Anreicherung und semiautomatisierte Detektion HER2-positiver zirkulierender Tumorzellen im Mammakarzinom
(2023-03-09)In clinical practice HER2 status has so far been determined using tissue samples from biopsies. As sample collection is an invasive, time-consuming procedure for patients, the focus is nowadays on blood-based biomarkers ... -
Cardiac microvascular dysfunction in diabetes mellitus: elucidation of molecular determinants and therapeutic targets
(2023-03-09)Microvascular dysfunction is a pathological hallmark of the diabetic myocardium, and is central to the etiology of diabetes-associated cardiac events. Herein, previous studies highlighted the role of the vasoactive micro-RNA ... -
Effekt von bioaktiven Nanopartikeln auf die Struktur, die physikalischen und die mechanischen Eigenschaften von dentalen Adhäsiven
(2023-03-08)In the present in vitro study, different nanoparticles were added to a commercial adhesive (Solobond Plus, VOCO GmbH, Cuxhaven, Germany). The modified adhesives were investigated with respect to their material properties ... -
Evaluation von Messinstrumenten bei der allergologischen Diagnostik vor und während einer spezifischen Immuntherapie mit Hymenopterengiftextrakt
(2023-03-07)Allergies against Hymenoptera venoms are one of the most common causes of severe anaphylactic reactions, besides food and drug allergies. The diagnosis of suspected Hymenoptera venom allergy consists of patient history, ... -
Vergleichende immunhistochemische Analyse onkogener Signalwegssignaturen in Lymphomen
(2023-03-03)B-cell lymphomas are a group of malign neoplasms derived from lymphoid B-cells. The targeted therapy of B-cell lymphomas includes the inhibition of oncogene signaling which is mediated via the B-cell receptor (BCR). However, ... -
Neuron-Glia Crosstalk: Investigating Immune-Cell Modulation in the CNP1 Null Mutant Mouse
(2023-03-01)Myelin sheaths built by oligodendrocytes in the central nervous system (CNS) are not only important insulators that enable the fast saltatory propagation of action potentials but also fulfill metabolic support functions ... -
Auswirkung von Enriched Environment auf hippocampalen Nervenzellverlust und Gedächtnisfunktionen im Mausmodell Tg4-42
(2023-02-27)N-truncated Aβ4-42 is one of the Aβ isoforms most frequently present in the brains of patients suffering from Alzheimer's disease. It exhibits an increased propensity for aggregation and increased toxicity, which can lead ... -
The MDM2 oncoprotein antagonizes Poly(ADP-ribosyl)ation
(2023-02-23)MDM2 is a target gene product and a negative regulator of the tumor suppressor p53. Additionally, MDM2 interferes with the progression of DNA replication forks. Poly(ADP-Ribose) Polymerase 1 (PARP1) is the main ...