s100β und Homocystein im Serum von stationär behandelten alkoholabhängigen Patienten als Verlaufsvariablen des akuten Alkoholentzugssyndroms

s100β und Homocystein im Serum von stationär behandelten alkoholabhängigen Patienten als Verlaufsvariablen des akuten Alkoholentzugssyndroms

Serum levels of S100B and homocysteine in alcohol-addicted inpatients as variables of the acute alcohol withdrawal syndrome

Karoline Neumann

Doctoral thesis

Date of Examination: 2014-01-21

Date of issue: 2014-01-21

Advisor: Wedekind, Dirk PD Dr.

Referee: Bachmann, Cornelius G. PD Dr.

Referee: Oppermann, Martin Prof. Dr.

Persistent Address: http://hdl.handle.net/11858/00-1735-0000-0022-5DFF-C

Files in this item

Name: DRKN3.3.pdf

Size: 984,6 KB

Format: PDF

View/Open

The following license files are associated with this item:

Creative Commons

Abstract

English

Elevations of serum homocysteine levels are a consistent finding in alcohol addiction. Serum S100B levels are altered in different neuropsychiatric disorders but not well investigated in alcohol withdrawal syndrome. Because of the close connection of S100B to ACTH and glutamate secretion, that both are involved in neurodegeneration and symptoms of alcoholism, the relationship of S100B and homocysteine to acute withdrawal variables has been examined. 22 male and 9 female inpatients (mean age 46.9±8.7 years) with an ICD-10 diagnosis of alcohol addiction and without relevant affective comorbidity were examined on admission and after 24, 48, and 120 hours during withdrawal. S100B and homocysteine levels in serum were collected and the initial serum ethanol-levels. The severity of withdrawal symptoms (AWS-scale), applied withdrawal medication and duration of addiction were recorded. Serum S100B and homocysteine levels declined significantly (p<.05) during the study period. Both levels declined simultaneously with withdrawal syndrome severity. Females showed a trend to a more intense decline in serum S100B levels compared to males at day 5 (p=.06). Homocysteine levels displayed a negative relationship to applied amount of clomethiazole (p<.05) and correlated with age of onset of addiction. No withdrawal seizures were recorded during the trial. As it is known for homocysteine, S100B revealed to decline rapidly over withdrawal treatment in alcoholism. This effect is more pronounced in female patients. S100B could be of relevance in the neurobiology of alcohol withdrawal syndromes. It may be indirectly related to the stress level or glutamatergic activity during alcohol withdrawal.

Keywords: alcohol addiction; homocysteine; s100β; withdrawal; S100B

Schlagwörter: Alkoholabhängigkeit; s100β; Alkoholentzug; Homocystein