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Die Rekonstruktion des Unterkiefers bei Knochendefekten mit einer Kombination aus rhBMP-2, einer synthetischen Polyethylenglycol-Matrix und Calciumphosphat -Eine Pilotstudie am Göttinger Minipig

The reconstruction of mandibular bone defects using a combination of rhBMP -2, a synthetic polyethylene glycol hydrogel and calcium phosphate -A pilot study in Göttingen minipigs

Sebastian Krohn
Doctoral thesis
Date of Examination: 2015-04-28
Date of issue: 2015-04-09
Advisor: Gruber, Rudolf M. PD Dr. Dr.
Referee: Gruber, Rudolf M. PD Dr. Dr.
Referee: Gersdorff, Nikolaus Prof. Dr.

Persistent Address: http://hdl.handle.net/11858/00-1735-0000-0022-5FA6-2

 

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Abstract

English

Aim: To test the hypothesis that a synthetic hydroxyapatite/beta-tricalcium phosphate (HA/TCP) construct combined with polyethylene glycol (PEG) hydrogel including recombinant human bone morphogenetic proteins-2 (rhBMP-2) enhances new bone formation compared with bone morphogenetic proteins-2 (BMP-2) delivered using the HA/TCP construct alone. Material and Methods: Bilateral mandibular partial thickness 20 x 8 x 8 mm (L x W x H) alveolar defects were surgically created in the edentulated posterior mandible in 18 female minipigs. Randomized into two groups of nine animals each, the alveolar defects either received HA/TCP or HA/TCP/PEG with or without BMP-2 (105 μg/defect) in contra-lateral sites using a split-mouth design. Primary outcome, bone density (%) within four regions of interest, was evaluated following a 4-week healing interval when the animals were killed for histomorphometric analysis. Results: Bone morphogenetic proteins-2 loaded onto HA/TCP constructs significantly enhanced new bone formation compared with HA/TCP controls. Adding PEG apparently obstructed BMP-2 induced bone formation. Conclusion: Polyethylene glycol compromises the osteogenic effect of BMP-2.
Keywords: bone morphogenetic protein 2; jawbone defects; maxillomandibular reconstruction; polyethylene glycol hydrogel
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