| dc.contributor.advisor | Lingor, Paul PD Dr. | |
| dc.contributor.author | Ostendorf, Thomas | |
| dc.date.accessioned | 2015-04-29T08:26:08Z | |
| dc.date.available | 2015-05-06T22:50:11Z | |
| dc.date.issued | 2015-04-29 | |
| dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0022-5FC7-7 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-5043 | |
| dc.language.iso | deu | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
| dc.subject.ddc | 610 | de |
| dc.title | Die Rolle von HGF für Neuroprotektion und axonale Regeneration im Nervus opticus der Ratte | de |
| dc.type | doctoralThesis | de |
| dc.title.translated | The role of HGF for neuroprotection and axonal regeneration in the optic nerve of rat | de |
| dc.contributor.referee | Lingor, Paul PD Dr. | |
| dc.date.examination | 2015-04-29 | |
| dc.description.abstracteng | Hepatocyte growth factor (HGF) is known to promote the
survival and foster neuritic outgrowth of different subpopulations
of CNS neurons during development. Together with
its corresponding receptor c-mesenchymal-epithelial transition
factor (Met), it is expressed in the developing and the
adult murine, rat and human CNS. We have studied the role
of HGF in paradigms of retinal ganglion cell (RGC) regeneration
and cell death in vitro and in vivo. After application
of recombinant HGF in vitro, survival of serum-deprived
RGC-5 cells and of growth factor-deprived primary RGC
was significantly increased. This was shown to be correlated
to the phosphorylation of c-Met and subsequent activation
of serine/threonine protein kinase Akt and MAPK
downstream signalling pathways involved in neuronal survival.
Furthermore, neurite outgrowth of primary RGC was
stimulated by HGF. In vivo, c-Met expression in RGC was
up-regulated after optic nerve axotomy lesion. Here, treatment
with HGF significantly improved survival of axotomized
RGC and enhanced axonal regeneration after optic nerve
crush. Our data demonstrates that exogenously applied
HGF has a neuroprotective and regeneration-promoting
function for lesioned CNS neurons. We provide strong evidence
that HGF may represent a trophic factor for adult
CNS neurons, which may play a role as therapeutic target
in the treatment of neurotraumatic and neurodegenerative
CNS disorders. | de |
| dc.contributor.coReferee | Reuss, Bernhard Prof. Dr. | |
| dc.subject.eng | retinal ganglion cells | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0022-5FC7-7-8 | |
| dc.affiliation.institute | Medizinische Fakultät | de |
| dc.subject.gokfull | Neurologie - Allgemein- und Gesamtdarstellungen (PPN619876247) | de |
| dc.description.embargoed | 2015-05-06 | |
| dc.identifier.ppn | 823756467 | |