• Deutsch
    • English
  • English 
    • Deutsch
    • English
  • Login
Item View 
  •   Home
  • Medizin
  • Human- und Zahnmedizin
  • Item View
  •   Home
  • Medizin
  • Human- und Zahnmedizin
  • Item View
JavaScript is disabled for your browser. Some features of this site may not work without it.

Die Bedeutung der Hedgehog- Signalkaskade in der Tumorgenese von spinalen und kraniellen Chordomen

The role of hedgehog signaling pathway in skull base and sacrum chordomas

by Amanda Angelika Klemer-Harcej née Harcej
Doctoral thesis
Date of Examination:2017-07-17
Date of issue:2017-07-13
Advisor:Prof. Dr. Veit Rohde
Referee:PD Dr. Imke Metz
Referee:PD Dr. Anja Uhmann
crossref-logoPersistent Address: http://dx.doi.org/10.53846/goediss-6393

 

 

Files in this item

Name:Dissertation Chordome_Amanda_Klemer-Harcej_eDiss.pdf
Size:1.80Mb
Format:PDF
ViewOpen

The following license files are associated with this item:


Abstract

English

Chordoma is a rare type of cancer that occurs in the bones of the skull base and spine, arising from remnants of embryonic notochord. Although they are slow growing, chordomas are highly recurrent, locally invasive and aggressive. Since chordomas arise in bone, they are usually extradural and result in local bone destruction. The prognosis of chordoma patients remains poorly. Radical surgery and high- dose radiation are the most useful treatment. Traditional chemotherapy has not been shown to be effective. Chordomas are complicated tumors to treat due to the involvement of critical structures such as the brainstem, spinal cord, and important nerves and arteries. Understanding the intracellular mechanisms of chordoma formation may help to develop an appropriate chemotherapeutic agent. The hedgehog pathway regulates multiple processes involved in development and differentiation of tissues and organs during embryonic life, as well as cell growth and differentiation in the adult organism, where the aberrant activation has been implicated in several cancers. To explore the role of hedgehog signaling in skull base and sacrum chordomas, we detected immuno histochemically the expression of Shh and Gli1, as well as Ptch1 and Gli1 by in- situ- hybridization. We assume a canonical, ligand- dependent and autocrine hedgehog signaling in skull base and sacral chordomas and their recurrences. A paracrine or non-canonical pathway cannot be excluded certainly. We anticipate that inhibitors of hedgehog pathway, like Shh-, Gli- and Smo- inhibitors, may have a positive clinical therapeutically effects for the treatment of chordomas.
Keywords: hedgehog signaling pathway; chordoma; hedgehog signaling pathway inhibitors; ptch1; gli1; shh; smo
 

Statistik

Publish here

Browse

All of eDissFaculties & ProgramsIssue DateAuthorAdvisor & RefereeAdvisorRefereeTitlesTypeThis FacultyIssue DateAuthorAdvisor & RefereeAdvisorRefereeTitlesType

Help & Info

Publishing on eDissPDF GuideTerms of ContractFAQ

Contact Us | Impressum | Cookie Consents | Data Protection Information
eDiss Office - SUB Göttingen (Central Library)
Platz der Göttinger Sieben 1
Mo - Fr 10:00 – 12:00 h


Tel.: +49 (0)551 39-27809 (general inquiries)
Tel.: +49 (0)551 39-28655 (open access/parallel publications)
ediss_AT_sub.uni-goettingen.de
[Please replace "_AT_" with the "@" sign when using our email adresses.]
Göttingen State and University Library | Göttingen University
Medicine Library (Doctoral candidates of medicine only)
Robert-Koch-Str. 40
Mon – Fri 8:00 – 24:00 h
Sat - Sun 8:00 – 22:00 h
Holidays 10:00 – 20:00 h
Tel.: +49 551 39-8395 (general inquiries)
Tel.: +49 (0)551 39-28655 (open access/parallel publications)
bbmed_AT_sub.uni-goettingen.de
[Please replace "_AT_" with the "@" sign when using our email adresses.]