Das Vorkommen von Matrilinen in dentalen und parodontalen Geweben der Wildtyp-Maus und der DDR1-Knockout-Maus

Eschholz, Robert

dc.contributor.advisor	Miosge, Nicolai Prof. Dr.
dc.contributor.author	Eschholz, Robert
dc.date.accessioned	2015-01-05T06:56:35Z
dc.date.available	2015-01-23T23:50:06Z
dc.date.issued	2015-01-05
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0023-9976-1
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-4845
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc	610	de
dc.title	Das Vorkommen von Matrilinen in dentalen und parodontalen Geweben der Wildtyp-Maus und der DDR1-Knockout-Maus	de
dc.type	doctoralThesis	de
dc.title.translated	The expression of matrilins in dental and periodontal tissues of the wildtype mouse and the DDR1 knockout mouse	de
dc.contributor.referee	Wiegand, Annette Prof. Dr.
dc.date.examination	2015-01-13
dc.description.abstracteng	DDRs are receptor tyrosine kinases that both bind collagens and are activated by fibrillar collagens. Using a knockout model, this thesis showed that the lack of DDR1 does not have an effect on the light microscopic structure and the ultrastructure of murine dental and periodontal tissues. Ultrastructurally, the PDL, a highly specialized tissue whose ECM is dominated by fibrillar collagens, did not show any abnormality either. This thesis is the first study to systematically perform the immunohistochemical detection of matrilin-1, -2, -3 and -4 in segments of jaws and molars of the wildtype mouse. Matrilins represent filament-forming and collagen-binding proteins of the ECM that can be detected particularly in cartilage and embryonic tissues. In this thesis, they were localized uniformly in the dental pulp, in the ECM of the PDL and in vascular walls in PDL and bone, respectively. Differences in the detectability of matrilin-1, -2, -3 and -4 in the wildtype mouse existed in coronal dentine and in lacunae of osteocytes. Thus, matrilins have a structural relevance in the ECM of murine dental and periodontal tissues. Matrilin-1, -2, -3 and -4 were also detected in dental and periodontal tissues of the DDR1 knockout mouse. By comparing the immunohistochemical results, this thesis showed that the DDR1 knockout does not have an effect on the biochemical composition of murine dental and periodontal tissues in terms of the immunohistochemical detectability of matrilins.	de
dc.contributor.coReferee	Oppermann, Martin Prof. Dr.
dc.subject.ger	DDR1	de
dc.subject.ger	PDL	de
dc.subject.ger	EZM	de
dc.subject.ger	Parodontium	de
dc.subject.ger	Matrilin	de
dc.subject.eng	DDR1	de
dc.subject.eng	PDL	de
dc.subject.eng	ECM	de
dc.subject.eng	Periodontium	de
dc.subject.eng	Matrilin	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0023-9976-1-2
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Zahn-, Mund- und Kieferheilkunde - Allgemein- und Gesamtdarstellungen (PPN619876360)	de
dc.description.embargoed	2015-01-23
dc.identifier.ppn	813463440

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Human- und Zahnmedizin [2873]

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