| dc.contributor.advisor | Morgenstern, Burkhard Prof. Dr. | |
| dc.contributor.author | Yasin, Layal | |
| dc.date.accessioned | 2016-03-29T10:51:53Z | |
| dc.date.available | 2016-03-29T10:51:53Z | |
| dc.date.issued | 2016-03-29 | |
| dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0028-870E-7 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-5583 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-5583 | |
| dc.language.iso | eng | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.ddc | 510 | de |
| dc.title | "Multiple Sequence Alignment Using External Sources Of Information" | de |
| dc.type | doctoralThesis | de |
| dc.contributor.referee | Damm, Carsten Prof. Dr. | |
| dc.date.examination | 2016-01-28 | |
| dc.description.abstracteng | Multiple sequence alignment is an alignment of three or more protein
or nucleic acid sequences. The alignment area has always been of much
interest for researchers, this is due to that fact that many scientifi c researchs
depend in their workflow on sequence alignments. Thus, having an alignment
of high quality is of high importance. Much work has been done and is
still carried in this field to help improving the quality of alignments. Many
approaches have been developed so far for performing pairwise and multiple
sequence alignments, yet, most of those approaches rely basically on the
sequences to be aligned as their only input. Recently, some approaches began
to incorporate additional sources of information in the alignment process, the
sources of external data can come from user knowledge or online databases.
This data, when integrated in the workflow of the alignment programs, may
add new constraints to the produced alignment and improve its quality
by making it biologically more meaningful. In this thesis, I will introduce
new approaches for multiple sequence alignment which use the alignment
software DIALIGN along with external information from databases, where
useful information is extracted and then integrated in the alignment process.
By testing those approaches on benchmark databases, I will show that
using additional data during alignment produced better results than using
DIALIGN alone without any external input other than the sequences to be
aligned. | de |
| dc.contributor.coReferee | Tout, Kifah Prof. Dr. | |
| dc.subject.eng | PFAM | de |
| dc.subject.eng | Alignment | de |
| dc.subject.eng | PROSITE | de |
| dc.subject.eng | DIALIGN | de |
| dc.subject.eng | Domains | de |
| dc.subject.eng | Patterns | de |
| dc.subject.eng | Profiles | de |
| dc.subject.eng | Multiple sequence alignment | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0028-870E-7-5 | |
| dc.affiliation.institute | Fakultät für Mathematik und Informatik | de |
| dc.subject.gokfull | Informatik (PPN619939052) | de |
| dc.identifier.ppn | 855347880 | |