Untersuchungen der lokalen Östrogenbiosynthese in Knorpelgewebe und chrondrogenen Progenitorzellen in späten Stadien der Arthrose

Untersuchungen der lokalen Östrogenbiosynthese in Knorpelgewebe und chrondrogenen Progenitorzellen in späten Stadien der Arthrose

Investigations of local estrogen biosynthesis in cartilage and chondrogenic progenitor cells in late stages of osteoarthritis

Marcus Reinermann

Doctoral thesis

Date of Examination: 2016-04-13

Date of issue: 2016-04-11

Advisor: Miosge, Nicolai Prof. Dr.

Referee: Gründker, Carsten Prof. Dr.

Referee: Schön, Margarete Prof. Dr.

Persistent Address: http://hdl.handle.net/11858/00-1735-0000-0028-8728-B

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Abstract

English

This work investigates local estrogen biosynthesis in chrondrogenic progenitor cells and cartilage of late-stage osteoarthritis (OA). Aromatase was found in cartilage taken from patients undergoing total knee replacement. It also was found in chondrogenic progenitor cells (CPC), a unique cell population in cartilage repair tissue with a high chondrogenic potential. Aromatase was present especially in CPC of elderly people. Also experiments were performed affect local estrogen biosynthesis in CPC to affect their ability to repair damaged cartilage. CPC exhibit the ability to produce local estrogen to perform auto- and paracrine effects and potentially increase their chrondrogenic potential. Induction of aromatization in CPC might be a way to decelerate the progression of OA, especially in elderly people.

Keywords: aromatase; osteoarthritis; chrondrogenic progentor cells