Wirkung von Ostarine – ein selektiver Androgenrezeptormodulator (SARM) – auf das osteoporotische Femur der orchiektomierten Ratte

Osteoporose, Sarm, Ostarine, Femur

Effect of Ostarine - a selective androgen receptor modulator (SARM) - on the osteoporotic femur of the orchiectomized rat

Osteoporosis, femur, Ostarine, Sarm

by Bastian R. Spelsberg
Doctoral thesis
Date of Examination:2022-07-27
Date of issue:2022-06-17
Advisor:Prof. Dr. Stephan Sehmisch
Referee:PD Dr. Daniel Hoffmann
Referee:Prof. Dr. Dirk Raddatz
Persistent Address: http://dx.doi.org/10.53846/goediss-9244

 

 

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Abstract

English

In this work, the drug ostarine, a selective androgen receptor modulator, was examined for its effectiveness in treating the osteoporotic femur of an orchiectomized rat. In the proximal femur, Testosteron Therapy improved cortical BMD in Orx rats. Ostarine Prophylaxe enhanced cortical density and volume, trabecular density and thickness, as well as the number of trabecular nodes.
Keywords: rat; osteoporosis; bone; Ostarine; sarm; testosteron
Schlagwörter: Osteoporose; Sarm; Knochenheilung; Knochen; Testosteron