Lipidemulsionen als Kontrastmittel für die Optische Kohärenztomographie zur Darstellung der Kammerwasserabflusswege

Gottschalk, Hanna Marie

dc.contributor.advisor	van Oterendorp, Christian PD Dr.
dc.contributor.author	Gottschalk, Hanna Marie
dc.date.accessioned	2023-03-31T08:31:26Z
dc.date.available	2023-04-07T00:50:26Z
dc.date.issued	2023-03-31
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/14603
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-9816
dc.format.extent	74	de
dc.language.iso	deu	de
dc.subject.ddc	610	de
dc.title	Lipidemulsionen als Kontrastmittel für die Optische Kohärenztomographie zur Darstellung der Kammerwasserabflusswege	de
dc.type	doctoralThesis	de
dc.title.translated	Lipid emulsions as contrast agents for OCT imaging of the aqueous outflow tract	de
dc.contributor.referee	van Oterendorp, Christian PD Dr.
dc.date.examination	2022-07-20	de
dc.description.abstracteng	Background: Glaucoma is one of the most common causes of blindness. Pathophysiologically, it is often caused by an obstruction of the aqueous outflow tract. Surgical interventions to improve the aqueous outflow are inconsistently effective, which may be due to a lack of localization of the outflow obstruction. To find an imaging technique that could visualize the aqueous humor outflow system, lipid emulsions (LE) were investigated as contrast agents for optical coherence tomography (OCT). Methods: Solutions of the anesthetic substance Propofol were infused into the anterior chamber of porcine eyes. Commercial OCT devices were applied to generate OCT images. The signal of the Propofol solution was extracted. A prototype lens for the anterior segment was used to perform OCT Angiography visualizing the LE drained via the aqueous outflow tract. For comparison with common methods fluorescence angiographic images were obtained after perfusion with indocyanine green. In addition, tissue samples were sliced after staining the aqueous veins with Trypan blue. Results: Lipid emulsions also produce a strong signal within the sclera ex vivo. It is possible to generate time-resolved images using LE-based OCT angiography. Moreover, significant anatomical differences were evident in the model eye compared to humans. In the porcine eye, no Schlemm’s canal existed and there was only a superficial but no deep venous plexus. Conclusions: The LE-based OCT angiography is a new imaging technique that allows to generate time-resolved 3D datasets of the aqueous outflow tract. Further studies are needed to determine possible interactions of LE with inner eye's structures, to improve image quality and to realize a visualization of the entire circumference of the eye.	de
dc.contributor.coReferee	Wouters, Fred Prof. Dr.
dc.contributor.thirdReferee	Staab, Wieland Prof. Dr.
dc.subject.ger	Glaukom	de
dc.subject.ger	Lipidemulsion	de
dc.subject.ger	Propofol	de
dc.subject.ger	Kammerwasserabfluss	de
dc.subject.ger	Optische Kohärenztomographie	de
dc.subject.ger	OCTA	de
dc.subject.eng	glaucoma	de
dc.subject.eng	lipid emulsion	de
dc.subject.eng	propofol	de
dc.subject.eng	aqueous outflow	de
dc.subject.eng	optical coherence tomography	de
dc.subject.eng	OCTA	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-14603-6
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.subject.gokfull	Ophthalmologie (PPN619876239)	de
dc.description.embargoed	2023-04-07	de
dc.identifier.ppn	1841010855
dc.notes.confirmationsent	Confirmation sent 2023-03-31T08:45:01	de

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Human- und Zahnmedizin [2874]

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