Lipocalin 2 als liquor und plasmabasierter Biomarker bei vaskulärer Enzephalopathie: Assoziationen mit klinischen Merkmalen und verschiedenen Formen der vaskulären Demenz

by Hanna Lindemann née Lindemann
Doctoral thesis
Date of Examination:2023-06-21
Date of issue:2023-05-30
Advisor:Dr. Peter Hermann
Referee:Prof. Dr. Inga Zerr
Referee:Dr. Niels Hansen
Referee:Prof. Dr. Margarete Schön
Persistent Address: http://dx.doi.org/10.53846/goediss-9889

 

 

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Abstract

English

Diagnosing vascular dementia can be a significant challenge due to numerous differential diagnoses and overlapping clinical features. To supplement current neuropsychological and imaging diagnostic tools with an objective and sensitive diagnostic tool, Lipocalin-2 concentrations have been proposed as biomarker for vascular dementia, but limited and inconsistent data are available. This study evaluates Lipocalin-2 concentrations in cerebrospinal fluid and serum in relation to vascular dementia, differential diagnoses, other biomarkers, and clinical data.
Keywords: vascular dementia; Lipocalin-2; mixed dementia; biomarker