Blättern Human- und Zahnmedizin nach Betreuer & Gutachter "Lehnart, Stephan E. Prof. Dr."
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Dreifarbige STED-Nanoskopie von Calcium-Freisetzungseinheiten in humanem linksventrikulären Gewebe verschiedener Subtypen hochgradiger Aortenklappenstenose
(2023-07-24)Confocal microscopy and STED nanoscopy of left ventricular myocardial biopsies from patients with severe aortic valve stenosis were used to investigate mechanisms of dysfunctional cardiac remodeling at the cellular and ... -
Development of a Novel Fluorescence Indicator System for the Characterization of Sarcomere Organization an Function in Human Cardiomyocytes
(2022-03-16)In this work, we describe a novel fluorescence indicator system for the in-vitro characterization of human stem cell-derived cardiomyocytes (hPSC-CM). We hypothesized that a) Z-lines in hPSC-CM can be reliably labeled via ... -
Strukturelle und funktionale Veränderungen der atrialen Kalzium-Freisetzungseinheit im Herzinsuffizienzmodell durch Junctophilin-2-Knockdown
(2021-03-05)In this work, the effects of a cardiac-specific tamoxifen-mediated junctophilin-2 (JPH2) knockdown in mice on structure and function of the atria and atrial cardiomyocytes (AM) were investigated. Atrial JPH2 protein ... -
Nanodomain clustering mechanisms of Junctophilin-2 in human kidney, cardiac and skeletal muscle cells
(2020-09-07)Junctophilin-2 (JPH2) –a tail-anchored protein located in the sarcoplasmic reticulum (SR) membrane– is known to stabilise Calcium Release Units (CRUs) in the ~12 nm wide junction between the sarcolemma (SL) and the SR. ... -
Über die differentielle Regulation von Ionenkanälen in spezifischen Nanodomänen atrialer und ventrikulärer Kardiomyozyten
(2017-05-19)Atrial cardiomyocytes express a transverse-axial tubule system, which is mainly composed of voluminous axial tubule (AT) components. Upon membrane depolarisation L-type calcium channels (Cav1.2) localised to AT sites ... -
Einfluss der Herzinsuffizienz auf Membranstrukturen und lokale cAMP-Dynamiken der SERCA2a-Mikrodomäne
(2016-10-17)Despite various therapeutic options, heart failure is still one of the main chronic diseases and causes of death in Western industrial nations. The signaling cascade of 3‘,5’-cyclic adenosine monophosphate (cAMP) plays a ...