Browsing Human- und Zahnmedizin by Advisor "Conradi, Lena-Christin PD Dr. Dr."
Now showing items 1-5 of 5
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Evaluation der Behandlung mit KAN0438757 in Kombination mit verschiedenen Chemotherapien im glykolytischen und lipogenen Subtyp des duktalen Pankreaskarzinoms
(2025-04-14)Despite current treatment options, the 5-year survival rate for patients with pancreatic ductal adenocarcinoma is below 10%. This highlights the relevance of new therapeutic approaches. Pancreatic ductal adenocarcinoma, ... -
Molekulare Charakterisierung von kolorektalen Lebermetastasen mit unterschiedlichen histopathologischen Wachstumsmustern
(2024-12-12)Colorectal cancer liver metastases express different histopathological growth patterns. The three common ones are the replacement, the desmoplastic, and the pushing histopathological growth patterns. Whereas the both latter ... -
Evaluation of desmoplastic and replacement type histopathological growth patterns of colorectal cancer liver metastases at single-cell resolution
(2024-09-10)This thesis project evaluated molecular differences between desmoplastic and replacement colorectal liver metastases, with the focus on the heterogeneity between ECs in livers colonized by CRCLM. Stratifying the sample ... -
PFKFB3-Inhibition während einer Radiochemotherapie des Rektumkarzinoms – Überprüfung in einem patient-derived xenograft In-vivo-Modell
(2024-01-29)Colorectal cancer (CRC) is the third most common cancer diagnosed worldwide and the second leading cause of cancer death. Approximately 30% of colorectal carcinomas are localized in the rectum. Neoadjuvant radiotherapy ... -
In vitro und in vivo Charakterisierung von KAN0438757 als Inhibitor des glykolytischen Enzyms PFKFB3 im kolorektalen Karzinom
(2023-08-01)Background: Colorectal cancer is the third most common cancer and the second leading cause of cancer-associated deaths worldwide. Despite early detection screening methods, approximately 25% of patients already have ...