Browsing Human- und Zahnmedizin by Advisor "Döppner, Prof. Dr. Thorsten Roland"
Now showing items 1-5 of 5
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Biologische Eigenschaften von circRNA_015350/006696 in Neuronen und Astrozyten unter hypoxischen Bedingungen
(2024-11-29)CircRNAs are a group of non-coding RNAs that have only recently been discovered. Many of the biological functions of circRNAs are not yet fully understood. It is currently assumed that circRNAs can act as miRNA sponges, ... -
Hypoxic Microglial Extracellular Vesicles Abrogate Poststroke AQP4 Depolarization, Astrogliosis and Neuroinflammation
(2023-11-03)Reactive astrogliosis, aquaporin 4 (AQP4) depolarization and neuroinflammation occurring and lasting for a long time in the periinfarct region are associated with poststroke brain injury. Our previous work has revealed ... -
Poststroke lipid droplet accumulation in residing microglia and its influence on inflammation
(2023-10-20)Microglia are critically involved in poststroke inflammation and thus affect neurological outcomes. Lipid droplet (LD) accumulation of microglia is dysfunctional in the aged brain and contributes to the worse outcome of ... -
Der Einfluss der Fettsäuresynthese auf die neuronale Schädigung nach Hypoxie und zerebraler Ischämie
(2022-04-22)In the context of a stroke, a cascade of reactions is induced at the cellular level, resulting in inflammation and apoptosis. Fatty acids play a pivotal role in cell metabolism - they can be generated de novo from carbon ... -
Extracellular vesicles derived from neural progenitor cells stimulate neuroregeneration in a rodent stroke model
(2022-03-02)Stem cells such as mesenchymal stem cells (MSCs) enhance neurological recovery in preclinical stroke models by secreting extracellular vesicles (EVs). Since previous reports have focused on the application of MSC-EVs only, ...