Browsing Human- und Zahnmedizin by Advisor "Hasenfuß, Gerd Prof. Dr."
Now showing items 1-14 of 14
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The role of RORβ in human iPSC derived cardiomyocytes
(2024-09-10)Every year systolic heart failure contributes immensely to the death tolls in industrialized nations. However, little is known about the molecular mechanisms underlying this devastating disease. Based on the RNA sequencing ... -
Functional CRISPR repair of induced pluripotent stem cells from patients with Noonan syndrome-associated cardiac hypertrophy
(2024-05-17)Noonan syndrome (NS) is a multisystemic disorder and characterised by its vast clinical variety including craniofacial dysmorphism, short stature and congenital heart defects resulting in severe pulmonary stenosis, ... -
Biallelic LZTR1 Mutations Activate RAS- MAPK Signaling and Cause Hypertrophic Cardiomyopathy in iPSC-Derived Cardiomyocytes of a Novel Type of Noonan Syndrome
(2023-02-06)Noonan syndrome is a multisystemic disorder with variable expressivity, characterized by typical craniofacial features, physical and mental retardation with cardiovascular abnormalities. Noonan syndrome is the most common ... -
The role of SFRP5 in cardiomyocyte function
(2022-06-17)Heart failure is one of the most common cause of death in Germany. The current treatment options are known to decelerate disease progression, but it cannot be halted or reversed. To date, the underlying molecular mechanisms ... -
Tiefe erweiterte Myektomie und Mobilisation des subvalvulären Mitralklappenapparates bei hypertropher obstruktiver Kardiomyopathie – Operative Ergebnisse und Risiken unter besonderer Berücksichtigung von Patienten mit vorheriger perkutaner transluminaler septaler Myokardablation
(2021-09-30)Hypertrophic cardiomyopathy (HCM) is a global disease of the myocardium with an incidence of 1:200 to 1:500 in the population. Possible clinical manifestations include sudden cardiac death, heart failure, and atrial ... -
Functional roles for chromogranin B
(2013-11-29)The versatility of intracellular calcium as a second messenger is evident by its ability to mediate such opposing events as neuronal cell growth and apoptosis. One leading hypothesis is that calcium regulates such divergent ... -
Zum Einfluss des Calcineurin and Ras binding protein (Carabin) auf die Wachstumsregulation von Kardiomyozyten
(2012-03-26)In cardiomyocytes Calcineurin-NFAT signaling and ERK/MAPK signaling play essential roles in the pathogenesis of cardiac hypertrophy and heart failure. The Calcineurin and Ras binding protein ... -
Intrakoronare Applikation von autologen adulten Stammzellen aus dem Knochenmark: Erste Erfahrungen mit einem Infarktmodell beim Schwein
(2012-01-30)Myocardial infarction is a common consequence of heart muscle damage and remains a major cause of morbidity and mortality worldwide. Bone marrow-derived cells may contribute to the healing ... -
Etablierung einer Methode zur Herstellung von adulten pluripotenten Stammzellen
(2011-10-17)The irreversible loss of cardiomyocytes after myocardial infarction can lead to chronic heart failure. A stem cell-based cell therapy could be a promising approach for organ regeneration. ... -
Nukleäre Funktionen des Muscle LIM Proteins in der Herzmuskelhypertrophie
(2011-05-26)In different pathologies of the heart a nuclear location of MLP, which was so far known primarily as a cytosceletal protein, has been observed. In the present work the localisation and ... -
Einfluss von Celecoxib auf die Entstehung und den Verlauf einer kardialen Hypertrophie
(2011-03-18)In human hearts, the transition from cardiac hypertrophy to advanced heart failure (HF) is accompanied by a tremendous increase in Akt phosphorylation. In non-myocardial tissue, the ... -
Induktion von myokardialem ER-Stress durch biomechanische Last und neurohumorale Stimulation.
(2010-08-03)Myocardial hypertrophy is an important adaptive response to various physiological and pathological stimuli. It can progress to maladaptive hypertrophy and finally heart failure. It is ... -
Untersuchung einer Calcineurin-bindungsdefizienten FKBP12.6-Mutante in Kardiomyozyten
(2010-07-26)The ryanodin receptor, the largest known ion channel of the heart muscle cell is known as a multi protein complex. It´s activity is regulated by proteins like kinases and phosphateses. ... -
Entwicklung und Erprobung eines in-vitro-Modellsystems zur Untersuchung von lastabhängigen Regulationsvorgängen der myokardialen Genexpression
(2007-01-31)The objective of this study was to develop a control setup for the culture of isotonically contracting muscle strip-preparations, based on an existing isometric long-term culture system. With this setup it would be possible ...