Blättern Human- und Zahnmedizin nach "Koch, Jan C. PD Dr." Betreuer
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Cytoskeletal assembly in axonal outgrowth and regeneration analyzed using STED microscopy
(2023-11-17)The cytoskeleton is essential for axon outgrowth and regeneration. It must be able to tolerate mechanical force and torsion while also allowing for adaptation and response to trauma or injury, such as axonal lesions. Recent ... -
Effekte einer pharmakologischen Inhibition der ULK1-Kinase auf die akute axonalen Degeneration in vivo
(2022-09-05)Background: Axonal degeneration is a key and early pathological feature in neurodegenerative and traumatic disorders of the central nervous system. A focal lesion to an axon is followed by a rapid disintegration within ... -
Der Einfluss von humanem Wildtyp-Alpha-Synuclein und seinen Mutationen A30P und A53T auf das Neuritenwachstum primärer dopaminerger Mittelhirnneurone der Ratte
(2021-01-11)Parkinson´s disease (PD) is the second most common neurodegenerative disease with increasing prevalence worldwide. Despite extensive research, current treatments of PD remain purely symptomatic while neuroprotective and ... -
Der Einfluss von humanem α-Synuclein-Wildtyp und der Mutanten A30P und A53T auf die Autophagie und den Transport synaptischer Vesikel in primären Mittelhirnneuronen der Ratte
(2020-09-29)Despite the expanding pathological understanding of Parkinson´s disease (PD) the relevant pathomechanisms are still not completely understood. Previous evidence suggests that disturbed cellular proteindegradation (autophagy) ... -
Live-Imaging von Kalzium-induzierter axonaler Degeneration in transgenen Mausmodellen des Morbus Parkinson
(2020-07-28)Introduction: In Parkinson’s Disease (PD), damage to axonal terminals precedes the loss of somata, which follows later in a “dying-back” pattern (axonal degeneration). The protein alpha-synuclein (aSyn) and its mutant forms ...