Browsing Human- und Zahnmedizin by Advisor "Lingor, Paul Prof. Dr."
Now showing items 1-8 of 8
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Analyse von Tränenflüssigkeit als Biomarkerquelle beim idiopathischen Parkinsonsyndrom
(2024-06-13)Background: The idiopathic Parkinson´s syndrome is one the second most common neurodegenerative diseases in the world. The diagnosis is to this day a mainly clinical diagnosis. The accuracy of the diagnosis is depending ... -
Pharmakologische rho-Kinasen-Inhibition im H4-Zelllinien-Modell des Morbus Parkinson
(2024-04-26)Parkinson's disease (PD) is the most common neurodegenerative movement disorder, unfortunately there are no curative therapeutic approaches to date. Rho-associated protein kinase (ROCK) has been described as a novel ... -
Regulation des Autophagieproteins ULK1 im MPTP-Mausmodell des Morbus Parkinson
(2022-11-08)Parkinson’s disease (PD) is a widespread neurodegenerative condition. Owing to the absence of suitable biomarkers, a diagnosis can only be made upon onset of clinical symptoms like tremor, rigidity or bradykinesia. They ... -
Tränenflüssigkeit als mögliche Quelle für Biomarker bei Patienten mit einem idiopathischem Parkinson-Syndrom
(2022-03-21)Idiopathic Parkinson's disease is the second most common neurodegenerative disorder worldwide with a growing prevalence in the continuously aging population. Until today, the diagnosis of Parkinson's disease is mainly based ... -
Role of autophagic protein ULK1 in axonal degeneration and regeneration in rat cortical neurons in vitro
(2021-11-02)In many traumatic and neurodegenerative disorders of the central nervous system, axonal degeneration is a central and early pathophysiological feature. Since the regenerative response of injured neurons is severely hampered ... -
Effects of the microRNA cluster 132/212 in primary dopaminergic neurons
(2021-02-19)The microRNA (miRNA) cluster 132/212 is highly involved in the regulation of cell growth and maturation in neurons and other cell types. This work investigated effects of increased levels of the miRNA strands miR-132-3p ... -
Kombinationsbehandlung mit Fasudil und Riluzol im SOD1-G93A-Mausmodell der Amyotrophen Lateralsklerose
(2018-03-26)The aim of this study was to test the beneficial effects of the Rho-Kinase inhibitor Fasudil on an established animal model, in which more than one hundred studies with different test substances had already been performed ... -
Pharmakologische Inhibition von Rho-Kinase im Mausmodell der Amyotrophen Lateralsklerose
(2015-06-12)Since the development of Riluzol no substance, which had been successfully tested in a preclinical setting before, has been able to be successful as a disease modifying drug in human ALS although there has been enormous ...