Browsing Human- und Zahnmedizin by Advisor "Zeisberg, Michael Prof. Dr."
Now showing items 1-6 of 6
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Bypass von mRNA-Qualitätskontrolle generiert aberrante EYA1-Isoform in tumorassoziierten Fibroblasten des Pankreas-CA
(2025-02-10)EYA1 plays a key role in the embryonic development of various organs. Further, it has a profibrotic effect, thus influencing the pathogenesis of various diseases and malignancies. Its tyrosine phosphatase activity and ... -
Relevanz von methylierten DNA-Fragmenten als nicht-invasiver Biomarker beim Nierenversagen
(2025-01-20)Epigenetic modifications, particularly DNA methylation, play a central role in the progression of acute and chronic kidney diseases. Early identification of at-risk patients and timely initiation of preventive measures are ... -
Protektive Effekte körperlicher Aktivität auf die Entwicklung der Nierenfibrose bei chronischer Niereninsuffizienz
(2024-12-20)The rising prevalence of chronic kidney disease (CKD) with its limited therapeutic options still poses a relevant clinical dilemma. Especially therapies that ameliorate the histopathological correlate, i.e. renal fibrosis, ... -
Untersuchung der pharmakologischen Modulation von ARNT-Homodimeren auf die Renoprotektion
(2023-10-02)Chronic kidney disease is marked by progressive fibrosis and consecutive loss of function – the availability of specific therapies is limited. The bHLH-PAS transcription factor ARNT is able to form homodimeric complexes ... -
Serelaxin-vermittelte Inhibition von Fibroblastenaktivierung bei renaler Fibrogenese
(2019-03-21)Progression of chronic kidney disease (CKD) towards end stage renal failure remains an unsolved problem in nephrology. Regardless of the primary underlying disease, chronically injured kidneys are histomorphologically ... -
Die Rolle des FK506 bei der Expression des BMP-Rezeptors BMPR1A
(2017-04-04)Chronic progressive kidney disease (CKD) represents an unsolved worldwide biomedical challenge because of lacking effective therapy strategies. At current state, only BMP7 and its chemically developed analogues reveal a ...