Browsing Human- und Zahnmedizin by Referee "Burckhardt, Gerhard Prof. Dr."

In-vitro-Analysen des organischen Kationentransporters OCT1 als hepatischer Aufnahmetransporter von Triptanen

Kuron, David (2017-05-29)

The low bioavailability of the anti-migraine drug sumatriptan is mainly caused by first-pass hepatic metabolism. I analyzed the impact of the hepatic organic cation transporter OCT1 and of OCT1 polymorphisms on sumatriptan ...

Einfluss des Transkriptionsfaktors B-cell lymphoma 6 (BCL6) auf die Expression renaler Transportproteine

Millé, Aline Noel (2016-10-26)

Renal cell carcinomia (RCC) is one of the ten most common and malignant tumor diseases worldwide. At current state, RCC represents 86% of all malignant kidney diseases. As medical research shows RCC is usually chemoresistant. ...

Grundlegende Untersuchungen zur erblichen Variation der Aktivitäten der Efflux-Transportproteine MDR1 und MRP2: Eine Zwillingsstudie mit Talinolol als In-vivo-Testsubstanz

Gal, Valerie Eva (2016-03-23)

BACKGROUND AND OBJECTIVES: The main objective of this study was to contribute to advancing personalized medicine, which means selecting the optimal drug in the optimal dose for each patient. For that it is necessary to ...

Transcriptional regulation of sex-dependently expressed renal organic anion transporter 1 and 3

Wegner, Waja (2013-02-11)

The renal organic anion transporters (OATs) play a pivotal role in the elimination of endogenous and exogenous substrates. In rats, an often used preclinical animal model, the basolateral located organic anion transporter ...

Einfluss eines Beatmungshelmes auf die Leistung zweier verschiedener Intensivbeatmungsgeräte im Vergleich zu einer Gesichtsmaske und zur invasiven Beatmung - Eine experimentelle Lungenmodelluntersuchung

Fischer, Sven (2012-09-27)

Noninvasive ventilation (NIV) is increasingly used in intensive care medicine, but only little information is available how different NIV interfaces affect the performance of a ventilatory system. Delay times, pressure ...