Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Advisor "Brose, Nils Prof. Dr."
Now showing items 1-10 of 10
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Analysis of protein SUMOylation and its role in Alzheimer's disease using mouse models
(2017-04-26)Post-translational modifications serve as a cellular mechanism for the regulation of the activity, stability and localization of proteins. SUMOylation is a dynamic and reversible post-translational modification, which ... -
Characterization of Synaptic Transmission Abnormalities in Neurological Disorders of the Presynaptic Terminal
(2022-03-04)Seminal methodological advancements in the field of human genetics now allow for low-cost sequencing of complete coding genomes, and rich sources of corresponding data now exist for healthy and patient cohorts, allowing ... -
Characterizing the SUMOylation of APC4 and the Function of APC4 Within Neurons
(2021-09-23)The Anaphase Promoting Complex (APC/C) is an E3 ubiquitin ligase that is involved in multiple molecular processes in eukaryotic cells. It is regulated by an intricate system of post-translational modifications that enables ... -
HECT-type Ubiquitin Ligases in Nerve Cell Development
(2016-10-11)Development of neurons begins in the middle of embryogenesis after closure of the neural tube. In the process of neurogenesis, neural stem cells generate nerve cells by asymmetric cell divisions at the ventricular zone of ... -
Large Dense Core Vesicle Exocytosis in Mouse Chromaffin Cells is Regulated by Munc13s and Baiap3
(2008-12-16)Members of mammalian uncoordinated 13 protein family (Munc13s) are essential for SV exocytosis in neurons and have also been implicated in LDCV exocytosis in chromaffin cells. However, ... -
Resolving the Ultrastructural Organization of Synaptic Vesicle Pools at Hippocampal Mossy Fiber and Schaffer Collateral Synapses
(2021-02-18)The synapse is the functional unit of chemical communication between neurons in the brain. In order to relay information with spatiotemporal precision, the presynaptic compartment utilizes a specialized molecular machinery ... -
SNAREs in evoked and spontaneous neurotransmission
(2010-02-04)The SNARE-complex consisting of synaptobrevin-2, SNAP-25, and syntaxin-1 is necessary for evoked synaptic transmission, but the involvement of the extended SNARE- bundle in different phases ... -
Synaptic Targeting of Neurotransmitter Receptors is Regulated by Neurobeachin
(2011-11-14)In neuronal network, information is transferred mainly via chemical synapses. Typically, a neuron receives thousands of inputs, which are transmitted by the activation of a large number of ... -
Targeting and Anchoring of Munc13-1 and ubMunc13-2 to active zones by RIM1alpha
(2005-11-23)Members of the Unc-13/Munc13 protein family are components of the presynaptic active zone and essential vesicle priming factors in regulated exocytosis. They are thought to mediate vesicle ... -
The Role of the Ras Guanyl-Nucleotide Exchange Factor Rasgrp1 in Synaptic Transmission
(2010-10-22)Ras signaling pathways are known to regulate neuronal development and function. Ras G proteins have been implicated in the differentiation of neurons, e.g. in dendrite and dendritic spine ...