Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Advisor "Dobbelstein, Matthias Prof. Dr."
Now showing items 1-6 of 6
-
The tumour suppressor p53 as a supporter of DNA replication
(2018-11-21)The tumour suppressor protein p53 is well known for its role in maintaining genetic stability by preventing the propagation of damage onto successive generations of cells. Depending on the extent of damage experienced by ... -
The kinase MK2 in DNA replication upon genotoxic stress and chemotherapy
(2013-01-11)DNA damage constitutes a constant threat to genomic integrity. Cells evolved programs controlled by a complex signaling network to cope with these lesions in order to avoid tumorigenesis. These cellular processes and ... -
The E2F1-responsive microRNA-449 promotes apoptosis
(2011-07-22)E2F1 is a positive regulator of cell cycle progression and also a potent inducer of apoptosis, especially when activated by DNA damage. To identify E2F1-inducible microRNAs, I performed ... -
Novel proapoptotic p63 isoforms are driven by an endogenous retrovirus in the male germ line of humans and great apes, likely increasing genome stability
(2011-05-04)TAp63, a homolog of the tumor suppressor p53, has the capability to protect the female germ line by eliminating oocytes that suffered severe DNA damage upon irradiation. Though expression ... -
p53 activity during adenovirus infection
(2010-06-24)Adenovirus is a small DNA tumour virus that has been extensively studied, leading to fundamental discoveries in molecular biology of mammalian cells. In particular, adenovirus oncoproteins ... -
Die Interferenz des Tumorsuppressor-Homologen p63 mit dem kanonischen Wnt-Signalweg
(2010-02-16)The tumor suppressor homologue p63 has an essential role in the proper development of squamous epithelia, limb buds and skin appendages, like hair follicles, teeth and glands. Another ...