Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Advisor "Fischer, André Prof. Dr."
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Loss of Setd1b methyltransferase in the murine forebrain as a novel model for human intellectual disability
(2020-12-22)Methylation of histone 3 lysine 4 (H3K4me3) is an epigenetic mark for active transcription, which is mediated in mammals by six enzymes of the SET1/MLL family of histone methyltransferases (KMTs). All of them have been ... -
From Chromatin Readers To Neuronal Networks: Finding New Treatments For Alzheimer´s Disease A Transcriptomics Approach
(2018-12-18)Alzheimer’s disease (AD) is the most common dementia-associated neurodegenerative disorder. It has detrimental social and economic impact not only on patients, but also their family and society as a whole. Current estimations ... -
Synaptic modifications in hippocampal CA3 pyramidal cells in an Alzheimer's mouse model
(2018-03-01)Memory encoding is thought to proceed from durable changes in the activity of synaptic circuits, leading to the storage of patterns of electrical events in a sparsely distributed ensemble of neurons. Located at the entry ... -
Amyloid-beta driven changes in transcriptome plasticity: From OMICS to Therapy
(2016-04-06)Alzheimer’s disease is characterized by a progressive cognitive decline coinciding with the formation of amyloid plaques and tau fibrils in the human brain. It is the most common form of dementia and the number of people ... -
Modulation of Histone Deacetylases Attenuates the Pathogenesis of Alzheimer's disease
(2011-04-12)SummaryWe are yet to learn precisely how we learn. The molecular and physiological mechanisms that govern the process of cognition remain a mystery to scientific minds around the globe. ...