Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Advisor "Kramer, Wilfried PD Dr."
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Untersuchungen zur Rolle von Mph1 aus Saccharomyces cerevisiae und seines menschlichen Orthologen FANCM bei der Erhaltung der genomischen Integrität
(2022-07-22)Living is life-threatening. Cells can only endure the diverse exogenous and endogenous attacks on their genome because they are equipped with a network of coordinated security measures: the DNA damage response. Repair ... -
Untersuchung der submitochondrialen Verteilung von Oxa1 und Mba1 in Saccharomyces cerevisiae
(2016-04-21)The mitochondria of eucaryotic cells are involved in several cellular processes and fulfill a multitude of fundamental tasks, such as the production of energy via the process of oxidative phosphorylation. They exhibit a ... -
Genetische Variabilität in der phagozytären NAD(P)H-Oxidase: Funktionelle Charakterisierung und Bedeutung für die Zytostatika-Therapie
(2010-01-05)Cardiotoxicity is a severe side effect of doxorubicin-containing chemotherapy as used in the treatment of several tumors and leukemia and up to 6% of treated patients develop congestive ... -
Pharmakogenetik des Zytostatikums Melphalan: Charakterisierung des Membrantransportes
(2009-01-06)Pharmacogenetics deals with genetically determined variation in how individuals respond to drugs. The alkylating agent melphalan - a bis (2-cloroethyl) amino derivative of the amino acid ... -
Saccharomyces cerevisiae DNA helicases Mph1, Srs2 and Sgs1 collaborate for the reinitiation of stalled or collapsed replication forks
(2006-08-10)The MPH1 gene from Saccharomyces cerevisiae codes for a DNA helicase involved in the error-free bypass of DNA lesions via homologous recombination. Simultaneous deletion of the MPH1 and ... -
Zur Substratspezifität und Substratbindung des periplasmatischen Chaperons SurA aus <i>Escherichia coli</i>
(2006-05-16)The Escherichia coli protein SurA which has been characterized as a periplasmic peptidyl-prolyl-isomerase (PPIase) and chaperon is involved in the maturation of trimeric outer ... -
Zur Funktion des MPH1-Gens von Saccharomyces cerevisiae bei der rekombinativen Umgehung von replikationsarretierenden DNA-Schäden
(2004-02-11)MPH1 from Saccharomyces cerevisiae codes for a protein of the DEAH family. Genetic interaction studies of mph1 mutants, which show an mutator phenotype and are sensitive to a variety of ... -
Untersuchungen zur Rolle des <i>MPH1</i>-Gens aus <i>Saccharomyces cerevisiae</i> bei der Reinitiation der Replikation nach schadensinduzierten Arresten
(2003-12-10)For the error-free removal of DNA damages the damaged bases are usually removed by mechanisms like nucleotide or base excision repair (NER, BER), mismatch repair etc. and the resulting gap ...