Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Advisor "Krebber, Heike Prof. Dr."
Now showing items 1-10 of 10
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A novel rRNA quality control function for Npl3 in Saccharomyces cerevisiae
(2024-03-25)In all domains of life, ribosomes are essential complexes that are the sole source for protein synthesis. Ribosome biosynthesis, the most energy-consuming process in a cell, has to be tightly regulated. Misregulation ... -
The complex formation of RNase P and RNase MRP in Saccharomyces cerevisiae
(2024-03-06)Ribonucleoproteins comprise a class of complexes that consist of RNAs and proteins. Riobozymes are catalytically active ribonucleoproteins that play a key role in the maturation of various RNAs. A prominent example is ... -
Characterization of Npl3 as a 5'- and 3'- quality control factor
(2023-09-11)Maturation of RNA polymerase II transcripts consists of 5’-capping, splicing, cleavage and 3’-polyadenylation. These processes can generate faulty transcripts that have to be retained in the nucleus to be degraded. An mRNA ... -
AntisenseRNA mediated gene regulation via double stranded RNA formation
(2023-03-01)The flow of genetic information in eukaryotic cells is established through transcription from the nuclear DNA into messenger (m)RNA, which travels into the cytoplasm for translation into proteins, the functional units of ... -
Nucleo-cytoplasmic shuttling of snoRNAs in Saccharomyces cerevisiae
(2022-07-19)Small nucleolar RNAs (snoRNAs) are a group of small non-coding RNAs involved in the post-transcriptional modification of RNAs, such as rRNA and tRNA. The importance of their role is evidenced by the rRNA regions subject ... -
Yeast cleavage factor Hrp1 is a novel guard protein that surveils pre-mRNA 3’ processing
(2022-05-10)Hrp1 is a component of the cleavage and polyadenylation complex (CPF-CF) for pre-mRNA cleavage and polyadenylation in S. cerevisiae. It specifically binds to a relatively conserved UA-rich domain called the efficiency-element ... -
The RNA helicase Dbp5/DDX19 regulates the ribosomal entry of eRF1-eRF3 and Dom34-Hbs1 in translation termination and cytoplasmic mRNA quality control
(2020-05-22)Translation is a highly regulated and quality-controlled process ensuring the production of correct polypeptides. Although translation initiation is a major target of regulation, translational control occurs also at the ... -
Charakterisierung des mRNA-Exportweges bei zellulärem Stress in Saccharomyces cerevisiae
(2016-11-15)In response to stress cells activate a prompt expression of stress-specific genes of which chaperones are essential in stabilizing and refolding proteins. In this situation stress-specific RNAs are selectively transcribed, ... -
Studies on the DEAD-box RNA-helicase Dbp5 and the ABC-protein Rli1 in translation termination and identification of a novel function of Dbp5 in ribosomal transport
(2015-09-03)The DEAD-box RNA-helicase Dbp5/Rat8 is well-known for its function in nuclear mRNA export. By using its Gle1 and IP6-stimulated ATPase activity, Dbp5 displaces export factors such as Mex67 from the mRNAs at the cytoplasmic ... -
Analyses of the Life Cycle of TLC1 and the Nuclear RNA Quality Control System in Saccharomyces cerevisiae
(2015-04-24)During genome replication, chromosomes undergo a progressive shortening of their ends. To counteract this loss, a complex named telomerase functions as a reverse transcriptase to elongate telomeres. In Saccharomyces ...