Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Advisor "Simons, Mikael Prof. Dr."
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Characterization of exosomes as a diagnostic marker in neurodegenerative diseases
(2016-10-28)α-Synuclein pathology has been hypothesized to propagate in synucleinopathies by intercellular transfer of pathogenic seeds in a prion-like fashion. Extracellular release of α-Synuclein via small extracellular vesicles has ... -
Analysis of Myelin Membrane Growth in Oligodendrocytes
(2015-12-07)Nervous systems of mammalian organisms are composed of various cell types with different morphology, function and connectivity. Understanding this complicity from a molecular point of view requires the application of ... -
Investigation of myelin membrane adhesion and compaction in the central nervous system
(2013-02-13)Myelin is a multi-layered membrane which enwraps the axons in peripheral (PNS) and central nervous system (CNS). The formation and assembly of this structure is a multi-step process that is regulated by a variety of ... -
Genome-wide RNAi screening reveals glial phosphoethanolamine ceramide is critical for axonal ensheathment
(2012-11-07)Glia play a major role in many processes during the development of the nervous system both in vertebrates and in invertebrates. One of the crucial functions of glia is the insulation of axons to provide them with trophic ... -
Mechanisms of Multivesicular Body Biogenesis and Exosome Release
(2010-06-10)Exosomes are small vesicles with a diameter of approximately 50-100 nm that are secreted by a number of different cells and function in a multitude of intercellular signaling processes. ...